| pubmed-article:19074677 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:19074677 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:19074677 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19074677 | pubmed:dateCreated | 2009-1-27 | lld:pubmed |
| pubmed-article:19074677 | pubmed:abstractText | Interleukin-10 (IL-10) is an anti-inflammatory cytokine with protective actions on the vasculature. On the other hand, endothelin (ET)-1 has potent vasoconstrictor, mitogenic, and proinflammatory activities, which have been implicated in the pathophysiology of a number of cardiovascular diseases. We hypothesized that, in a condition where ET-1 expression is upregulated, i.e., on infusion of TNF-alpha, IL-10 confers vascular protection from ET-1-induced injury. Aortic rings and first-order mesenteric arteries from male C57BL/6 (WT) and IL-10-knockout (IL-10(-/-)) mice were treated with human recombinant TNF-alpha (220 ng x kg(-1) x day(-1)) or vehicle (saline) for 14 days. TNF-alpha infusion significantly increased blood pressure in IL-10(-/-), but not WT, mice. TNF-alpha augmented vascular ET-1 mRNA expression in arteries from WT and IL-10(-/-) mice. ET type A (ET(A)) receptor expression was increased in arteries from IL-10(-/-) mice, and TNF-alpha infusion did not change vascular ET(A) receptor expression in control or IL-10(-/-) mice. Aorta and mesenteric arteries from TNF-alpha-infused IL-10(-/-) mice displayed increased contractile responses to ET-1, but not the ET type B receptor agonist IRL-1620. The ET(A) receptor antagonist atrasentan completely abolished responses to ET-1 in aorta and mesenteric vessels, whereas the ERK1/2 inhibitor PD-98059 abrogated increased contractions to ET-1 in arteries from TNF-alpha-infused IL-10(-/-) mice. Infusion of TNF-alpha, as well as knockdown of IL-10 (IL-10(-/-)), induced an increase in total and phosphorylated ERK1/2. These data demonstrate that IL-10 counteracts ET(A)-mediated vascular responses to ET-1, as well as activation of the ERK1/2 pathway. | lld:pubmed |
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| pubmed-article:19074677 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19074677 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19074677 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19074677 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19074677 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19074677 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:19074677 | pubmed:author | pubmed-author:ErgulAdviyeA | lld:pubmed |
| pubmed-article:19074677 | pubmed:author | pubmed-author:WebbR... | lld:pubmed |
| pubmed-article:19074677 | pubmed:author | pubmed-author:CalleraGlauci... | lld:pubmed |
| pubmed-article:19074677 | pubmed:author | pubmed-author:TostesRita... | lld:pubmed |
| pubmed-article:19074677 | pubmed:author | pubmed-author:ZemseSaiprasa... | lld:pubmed |
| pubmed-article:19074677 | pubmed:author | pubmed-author:GiachiniFerna... | lld:pubmed |
