| pubmed-article:1906177 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C1523873 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C1420192 | lld:lifeskim |
| pubmed-article:1906177 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:1906177 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:1906177 | pubmed:dateCreated | 1991-8-14 | lld:pubmed |
| pubmed-article:1906177 | pubmed:abstractText | Precursors of B cells, which constitute a subpopulation of the lymphocytes in bone marrow, can be identified by their surface expression of nonimmunoglobulin markers and the absence of immunoglobulin kappa and lambda light chains. Most pre-B cells synthesize mu heavy chains but, without light-chain partners, these undergo rapid cytoplasmic degradation. In the present study, we demonstrate that late stage pre-B cells, like their neoplastic counterparts, express low levels of a surface receptor composed of mu chains paired with a surrogate light-chain complex formed by Vpre-B and lambda 5-like proteins. The data define a previously suspected but unrecognized stage in normal pre-B-cell differentiation. Expression of a clonally diverse receptor renders this population of immature B-lineage cells potentially vulnerable to clonal selection by antigens and idiotypic interactions. | lld:pubmed |
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| pubmed-article:1906177 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1906177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1906177 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1906177 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1906177 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1906177 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1906177 | pubmed:author | pubmed-author:OhnoTT | lld:pubmed |
| pubmed-article:1906177 | pubmed:author | pubmed-author:NishimotoNN | lld:pubmed |
| pubmed-article:1906177 | pubmed:author | pubmed-author:CooperM DMD | lld:pubmed |
| pubmed-article:1906177 | pubmed:author | pubmed-author:KubagawaHH | lld:pubmed |
| pubmed-article:1906177 | pubmed:author | pubmed-author:StankovicA... | lld:pubmed |
| pubmed-article:1906177 | pubmed:author | pubmed-author:GartlandG LGL | lld:pubmed |
| pubmed-article:1906177 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1906177 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1906177 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1906177 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1906177 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1906177 | pubmed:pagination | 6284-8 | lld:pubmed |
| pubmed-article:1906177 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1906177 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1906177 | pubmed:articleTitle | Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins. | lld:pubmed |
| pubmed-article:1906177 | pubmed:affiliation | Department of Medicine, University of Alabama, Birmingham. | lld:pubmed |
| pubmed-article:1906177 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1906177 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1906177 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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