| pubmed-article:19059245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C0225325 | lld:lifeskim |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C0032176 | lld:lifeskim |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C1422611 | lld:lifeskim |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19059245 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19059245 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19059245 | pubmed:dateCreated | 2008-12-29 | lld:pubmed |
| pubmed-article:19059245 | pubmed:abstractText | Novel synthetic collagen fibers, poly(PHG) made by polycondensation of Pro-Hyp-Gly, spontaneously assume polymeric structure with molecular weights greater than 10(5). Its application for biomaterials has been explored, but that for a platelet agonist has not been investigated. Poly(PHG)-induced platelet aggregation independently of thromboxane A(2) and integrin alpha2beta1. Poly(PHG)-induced tyrosine phosphorylation of glycoprotein VI (GPVI)-related molecules and failed to activate GPVI/FcRgamma-deficient platelets. Binding of GPVI to poly(PHG) was confirmed by a surface plasmon resonance spectroscopy, suggesting that poly(PHG) activates platelets through GPVI. Poly(PHG) is an useful research tool to investigate GPVI-mediated signals and a substitute for collagen in platelet functional assays. | lld:pubmed |
| pubmed-article:19059245 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19059245 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19059245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19059245 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19059245 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:InoueOsamuO | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:OzakiYukioY | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:Suzuki-InoueK... | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:ShinodaDaisuk... | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:UmedaYasutoY | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:UchinoMasazum... | lld:pubmed |
| pubmed-article:19059245 | pubmed:author | pubmed-author:TakasakiSin-i... | lld:pubmed |
| pubmed-article:19059245 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19059245 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:19059245 | pubmed:volume | 583 | lld:pubmed |
| pubmed-article:19059245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19059245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19059245 | pubmed:pagination | 81-7 | lld:pubmed |
| pubmed-article:19059245 | pubmed:dateRevised | 2009-3-12 | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:meshHeading | pubmed-meshheading:19059245... | lld:pubmed |
| pubmed-article:19059245 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19059245 | pubmed:articleTitle | Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI. | lld:pubmed |
| pubmed-article:19059245 | pubmed:affiliation | Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. | lld:pubmed |
| pubmed-article:19059245 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:14127 | entrezgene:pubmed | pubmed-article:19059245 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19059245 | lld:pubmed |
