| pubmed-article:19056685 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0019360 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0174680 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0015272 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19056685 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19056685 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19056685 | pubmed:dateCreated | 2009-2-2 | lld:pubmed |
| pubmed-article:19056685 | pubmed:abstractText | Here, we have studied the effect of the tight junction protein zona occludens (ZO)-2 on cyclin D1 (CD1) protein expression. CD1 is essential for cell progression through the G1 phase of the cell cycle. We have found that in cultures of synchronized Madin-Darby canine kidney cells, ZO-2 inhibits cell proliferation at G0/G1 and decreases CD1 protein level. These effects occur in response to a diminished CD1 translation and an augmented CD1 degradation at the proteosome triggered by ZO-2. ZO-2 overexpression decreases the amount of Glycogen synthase kinase-3beta phosphorylated at Ser9 and represses beta-catenin target gene expression. We have also explored the expression of ZO-2 through the cell cycle and demonstrate that ZO-2 enters the nucleus at the late G1 phase and leaves the nucleus when the cell is in mitosis. These results thus explain why in confluent quiescent epithelia ZO-2 is absent from the nucleus and localizes at the cellular borders, whereas in sparse proliferating cultures ZO-2 is conspicuously present at the nucleus. | lld:pubmed |
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| pubmed-article:19056685 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19056685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19056685 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19056685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19056685 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19056685 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19056685 | pubmed:issn | 1939-4586 | lld:pubmed |
| pubmed-article:19056685 | pubmed:author | pubmed-author:IslasSocorroS | lld:pubmed |
| pubmed-article:19056685 | pubmed:author | pubmed-author:HuberOtmarO | lld:pubmed |
| pubmed-article:19056685 | pubmed:author | pubmed-author:González-Mari... | lld:pubmed |
| pubmed-article:19056685 | pubmed:author | pubmed-author:HuertaMiriamM | lld:pubmed |
| pubmed-article:19056685 | pubmed:author | pubmed-author:Lopez-Bayghen... | lld:pubmed |
