Linked Life Data

19049803

Source:http://linkedlifedata.com/resource/pubmed/id/19049803

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19049803rdf:typepubmed:Citationlld:pubmed
pubmed-article:19049803lifeskim:mentionsumls-concept:C0044602lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0285761lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1368105lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1451005lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1705325lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0225336lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C2350570lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0242643lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0021641lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1882598lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0033634lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0079904lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1150481lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1704259lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C1705987lld:lifeskim
pubmed-article:19049803lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:19049803pubmed:issue2-3lld:pubmed
pubmed-article:19049803pubmed:dateCreated2009-1-12lld:pubmed
pubmed-article:19049803pubmed:abstractTextOur previous study showed that insulin restored impaired function and expression of P-glycoprotein in diabetic blood-brain barrier, and further study showed that insulin up-regulated P-glycoprotein expression and function in normal blood-brain barrier, so insulin might be one of the factors that regulated the function and expression of P-glycoprotein in blood-brain barrier of diabetes. In this study, the intracellular pathways that insulin regulated the P-glycoprotein were investigated using primarily cultured rat brain microvessel endothelial cells model. The rat brain microvessel endothelial cells were incubated in normal culture medium containing 50 mU/l insulin and different concentrations of inhibitors for 72 h. The P-glycoprotein function and expression in the rat brain microvessel endothelial cells were assessed using the uptake of P-glycoprotein substrate rhodamine 123 and western blot assay, respectively. It was found that treatment of 50 mU/l insulin significantly increased P-glycoprotein function and expression in rat brain microvessel endothelial cells. This induced effect was blocked by insulin receptor antibody, insulin receptor tyrosine kinase inhibitor I-OMe-AG538, PKC inhibitor chelerythrine and NF-kappaB inhibitor pyrrolidine dithiocarbamate ammonium (PDTC). But this induced effect was not inhibited by phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor LY294002. These results indicated that insulin regulated P-glycoprotein function and expression through signal transduction pathways involving activation of PKC/NF-kappaB but not PI3K/Akt pathway.lld:pubmed
pubmed-article:19049803pubmed:languageenglld:pubmed
pubmed-article:19049803pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:citationSubsetIMlld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19049803pubmed:statusMEDLINElld:pubmed
pubmed-article:19049803pubmed:monthJanlld:pubmed
pubmed-article:19049803pubmed:issn1879-0712lld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:SzeS HSHlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:YangLiLlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:LiuHaiyanHlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:LiuXiaodongXlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:LiuYuchunYlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:YangHuiwenHlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:WangGuangJiGlld:pubmed
pubmed-article:19049803pubmed:authorpubmed-author:WangDianleiDlld:pubmed
pubmed-article:19049803pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19049803pubmed:day14lld:pubmed
pubmed-article:19049803pubmed:volume602lld:pubmed
pubmed-article:19049803pubmed:ownerNLMlld:pubmed
pubmed-article:19049803pubmed:authorsCompleteYlld:pubmed
pubmed-article:19049803pubmed:pagination277-82lld:pubmed
pubmed-article:19049803pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:meshHeadingpubmed-meshheading:19049803...lld:pubmed
pubmed-article:19049803pubmed:year2009lld:pubmed
pubmed-article:19049803pubmed:articleTitleInsulin regulates P-glycoprotein in rat brain microvessel endothelial cells via an insulin receptor-mediated PKC/NF-kappaB pathway but not a PI3K/Akt pathway.lld:pubmed
pubmed-article:19049803pubmed:affiliationCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.lld:pubmed
pubmed-article:19049803pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19049803pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:24954entrezgene:pubmedpubmed-article:19049803lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:19049803lld:entrezgene