Linked Life Data

19047098

Source:http://linkedlifedata.com/resource/pubmed/id/19047098

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2008-12-2
pubmed:abstractText
As favorable outcomes from malignant brain tumors remain limited by poor survival and treatment-related toxicity, novel approaches to cure are essential. Previously, we identified the cyclic AMP phosphodiesterase-4 (PDE4) inhibitor Rolipram as a potent antitumor agent. Here, we investigate the role of PDE4 in brain tumors and examine the utility of PDE4 as a therapeutic target.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7717-25
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed-meshheading:19047098-Adolescent, pubmed-meshheading:19047098-Adult, pubmed-meshheading:19047098-Aged, pubmed-meshheading:19047098-Animals, pubmed-meshheading:19047098-Antineoplastic Agents, pubmed-meshheading:19047098-Blotting, Western, pubmed-meshheading:19047098-Brain Neoplasms, pubmed-meshheading:19047098-Cell Line, Tumor, pubmed-meshheading:19047098-Child, pubmed-meshheading:19047098-Child, Preschool, pubmed-meshheading:19047098-Combined Modality Therapy, pubmed-meshheading:19047098-Cyclic Nucleotide Phosphodiesterases, Type 4, pubmed-meshheading:19047098-Dacarbazine, pubmed-meshheading:19047098-Female, pubmed-meshheading:19047098-Humans, pubmed-meshheading:19047098-Immunohistochemistry, pubmed-meshheading:19047098-Male, pubmed-meshheading:19047098-Mice, pubmed-meshheading:19047098-Middle Aged, pubmed-meshheading:19047098-Phosphodiesterase Inhibitors, pubmed-meshheading:19047098-Rolipram, pubmed-meshheading:19047098-Xenograft Model Antitumor Assays
pubmed:year
2008
pubmed:articleTitle
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.
pubmed:affiliation
Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural