| pubmed-article:19046819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0036866 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0205065 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0015689 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:19046819 | lifeskim:mentions | umls-concept:C0556150 | lld:lifeskim |
| pubmed-article:19046819 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19046819 | pubmed:dateCreated | 2009-3-24 | lld:pubmed |
| pubmed-article:19046819 | pubmed:abstractText | The two-fold higher prevalence rate of major depression in females may involve vulnerability to omega-3 fatty acid deficiency secondary to a dysregulation in ovarian hormones. However, the role of ovarian hormones in the regulation of brain omega-3 fatty acid composition has not been directly evaluated. Here we determined erythrocyte and regional brain docosahexaenoic acid (DHA, 22:6n-3) composition in intact male and female rats, and in chronically ovariectomized (OVX) rats with or without cyclic estradiol treatment (2 microg/4d). All groups were maintained on diets with or without the DHA precursor alpha-linolenic acid (ALA, 18:3n-3). We report that both male (-21%) and OVX (-19%) rats on ALA+ diet exhibited significantly lower erythrocyte DHA composition relative to female controls. Females on ALA+ diet exhibited lower DHA composition in the prefrontal cortex (PFC) relative males (-5%). OVX rats on ALA+ diet exhibited significantly lower DHA composition in the hippocampus (-6%), but not in the PFC, hypothalamus, or midbrain. Lower erythrocyte and hippocampus DHA composition in OVX rats was not prevented by estrogen replacement. All groups maintained on ALA- diet exhibited significantly lower erythrocyte and regional brain DHA composition relative to groups on ALA+ diet, and these reductions were greater in males but not in OVX rats. These preclinical data corroborate clinical evidence for gender differences in peripheral DHA composition (female>male), demonstrate gender differences in PFC DHA composition (male>female), and support a link between ovarian hormones and erythrocyte and region-specific brain DHA composition. | lld:pubmed |
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| pubmed-article:19046819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19046819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19046819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19046819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19046819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19046819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19046819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19046819 | pubmed:month | May | lld:pubmed |
| pubmed-article:19046819 | pubmed:issn | 0306-4530 | lld:pubmed |
| pubmed-article:19046819 | pubmed:author | pubmed-author:TsoPatrickP | lld:pubmed |
| pubmed-article:19046819 | pubmed:author | pubmed-author:McNamaraRober... | lld:pubmed |
| pubmed-article:19046819 | pubmed:author | pubmed-author:JandacekRonal... | lld:pubmed |
| pubmed-article:19046819 | pubmed:author | pubmed-author:RiderThereseT | lld:pubmed |
| pubmed-article:19046819 | pubmed:author | pubmed-author:AbleJessicaJ | lld:pubmed |
| pubmed-article:19046819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19046819 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:19046819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19046819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19046819 | pubmed:pagination | 532-9 | lld:pubmed |
| pubmed-article:19046819 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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