| pubmed-article:19046403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0456603 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C0962722 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C1723136 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C1869507 | lld:lifeskim |
| pubmed-article:19046403 | lifeskim:mentions | umls-concept:C2354310 | lld:lifeskim |
| pubmed-article:19046403 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19046403 | pubmed:dateCreated | 2008-12-19 | lld:pubmed |
| pubmed-article:19046403 | pubmed:abstractText | In neurons, Presenilin 1(PS1)/gamma-secretase is located at the synapses, bound to N-cadherin. We have previously reported that N-cadherin-mediated cell-cell contact promotes cell-surface expression of PS1/gamma-secretase. We postulated that N-cadherin-mediated trafficking of PS1 might impact synaptic PS1-amyloid precursor protein interactions and Abeta generation. In the present report, we evaluate the effect of N-cadherin-based contacts on Abeta production. We demonstrate that stable expression of N-cadherin in Chinese hamster ovary cells, expressing the Swedish mutant of human amyloid precursor protein leads to enhanced secretion of Abeta in the medium. Moreover, N-cadherin expression decreased Abeta(42/40) ratio. The effect of N-cadherin expression on Abeta production was accompanied by the enhanced accessibility of PS1/gamma-secretase to amyloid precursor protein as well as a conformational change of PS1, as demonstrated by the fluorescence lifetime imaging technique. These results indicate that N-cadherin-mediated synaptic adhesion may modulate Abeta secretion as well as the Abeta(42/40) ratio via PS1/N-cadherin interactions. | lld:pubmed |
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| pubmed-article:19046403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19046403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19046403 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19046403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19046403 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19046403 | pubmed:issn | 1471-4159 | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:ShimohamaShun... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:HymanBradley... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:SugimotoHachi... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:UemuraKengoK | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:KinoshitaAyae... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:BerezovskaOks... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:AndoKoichiK | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:TakahashiRyos... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:KiharaTakeshi... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:KubotaMasakaz... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:NishimotoTaka... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:AoyagiNobuhis... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:LillChristina... | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:BanksMaryM | lld:pubmed |
| pubmed-article:19046403 | pubmed:author | pubmed-author:AsadaMegumiM | lld:pubmed |
| pubmed-article:19046403 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19046403 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:19046403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19046403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19046403 | pubmed:pagination | 350-60 | lld:pubmed |
| pubmed-article:19046403 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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