| pubmed-article:19036925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C1415066 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C1819457 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19036925 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:19036925 | pubmed:issue | 49 | lld:pubmed |
| pubmed-article:19036925 | pubmed:dateCreated | 2008-12-10 | lld:pubmed |
| pubmed-article:19036925 | pubmed:abstractText | T helper 2 (Th2) cells are critical to the induction of IgE antibody and allergic inflammation, but how the pathological pathways are controlled in nonallergic individuals remains unclear. Here we report that glycosylation-inhibiting factor (GIF) suppresses Th2 effector generation. GIF is a cytokine encoded by the same gene that codes for macrophage migration inhibitory factor (MIF). GIF-deficient mice demonstrated enhanced T-dependent antibody formation especially of IgE isotype and allergic airway inflammation with the generation of regulatory T cells unaffected. GIF-deficient macrophages and dendritic cells revealed normal responsiveness to toll-like receptor (TLR) ligands. GIF undergoes a unique posttranslational modification, cysteinylation. The modified GIF, mainly secreted by activated T cells derived from CD4(+)CD25(-) cells, inhibited IL-4 production by the same cells whereas the unmodified GIF showed no effect. Bone marrow chimera experiment demonstrated that T cell-derived GIF suppressed the generation of Th effectors that secrete IL-4. During the first 24 h of CD3/CD28 stimulation in vitro, GIF secreted from naïve CD4 cells acted on the same cells, maintained nuclear factor of activated T cells (NFAT)c2 in the nucleus, and repressed IL-4 mRNA levels. Thus, GIF represents a self-regulatory mechanism of Th2 cell generation from naïve CD4 cells, in which the posttranslational modification plays a crucial role. | lld:pubmed |
| pubmed-article:19036925 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19036925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19036925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19036925 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19036925 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19036925 | pubmed:author | pubmed-author:JanssenEdith... | lld:pubmed |
| pubmed-article:19036925 | pubmed:author | pubmed-author:SugieKatsujiK | lld:pubmed |
| pubmed-article:19036925 | pubmed:author | pubmed-author:Kim-SaijoMisa... | lld:pubmed |
| pubmed-article:19036925 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19036925 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:19036925 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:19036925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19036925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19036925 | pubmed:pagination | 19402-7 | lld:pubmed |
| pubmed-article:19036925 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:meshHeading | pubmed-meshheading:19036925... | lld:pubmed |
| pubmed-article:19036925 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:19036925 | pubmed:articleTitle | CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production. | lld:pubmed |
