Linked Life Data

190222

Source:http://linkedlifedata.com/resource/pubmed/id/190222

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:190222rdf:typepubmed:Citationlld:pubmed
pubmed-article:190222lifeskim:mentionsumls-concept:C1623048lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0035286lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0007625lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0040711lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0035696lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0205345lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C1323391lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0982459lld:lifeskim
pubmed-article:190222lifeskim:mentionsumls-concept:C0049942lld:lifeskim
pubmed-article:190222pubmed:issue4lld:pubmed
pubmed-article:190222pubmed:dateCreated1977-4-15lld:pubmed
pubmed-article:190222pubmed:abstractTextVesicular stomatitis virus mRNAs with these four types of 5'-termini, (a) m7G5'ppp5'(m)Am, (b) ppp5'(m)Am, (c) m7G5'-ppp5' Am, and (d) G5'ppp5'A, were prepared and their translation and ribosome binding analyzed in wheat germ and reticulocyte cell-free protein synthesis systems. The relative efficiencies of translation of individual vesicular stomatitis virus (VSV) mRNAs having type 2 termini ranged from 23 to 29% of the control (type 1) RNA in the reticulocyte system and 6 to 7% of control RNA in the wheat germ system. A similar difference between the two systems was seen in ribosome-binding experiments in which type 2 RNA formed an 80 S initiation complex with high efficiency (70% of control type 1 RNA) in the reticulocyte system, but with low efficiency (17% of control RNA) in the wheat germ system. Similar differences in the importance of m7G in translation in the two systems were seen when VSV mRNAs synthesized in vitro with type 3 and type 4 termini were analyzed. However, the analysis of type 4 RNA (which was synthesized in vitro in the presence of S-adenosylhomocysteine) was complicated by the presence of abnormally large poly(A) at its 3'-end. Another series of experiments showed that compounds such as 5'pm7G and m7G5'ppp5'Np are potent and specific inhibitors of translation of all types of VSV mRNAs in the wheat germ system (greater than 98% inhibition) but cause less than 20% inhibition of translation in the reticulocyte system. Taken together, all of the results indicate that a 5'-terminal m7G is far more important in translation of VSV mRNAs in the heterologous plant cell-free system than in the reticulocyte lysate system.lld:pubmed
pubmed-article:190222pubmed:languageenglld:pubmed
pubmed-article:190222pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:190222pubmed:citationSubsetIMlld:pubmed
pubmed-article:190222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:190222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:190222pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:190222pubmed:statusMEDLINElld:pubmed
pubmed-article:190222pubmed:monthFeblld:pubmed
pubmed-article:190222pubmed:issn0021-9258lld:pubmed
pubmed-article:190222pubmed:authorpubmed-author:LodishH FHFlld:pubmed
pubmed-article:190222pubmed:authorpubmed-author:RoseJ KJKlld:pubmed
pubmed-article:190222pubmed:issnTypePrintlld:pubmed
pubmed-article:190222pubmed:day25lld:pubmed
pubmed-article:190222pubmed:volume252lld:pubmed
pubmed-article:190222pubmed:ownerNLMlld:pubmed
pubmed-article:190222pubmed:authorsCompleteYlld:pubmed
pubmed-article:190222pubmed:pagination1181-8lld:pubmed
pubmed-article:190222pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-A...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-P...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-T...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-R...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-S...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-K...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-R...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-G...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-R...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-P...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-R...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-R...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-V...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-C...lld:pubmed
pubmed-article:190222pubmed:meshHeadingpubmed-meshheading:190222-P...lld:pubmed
pubmed-article:190222pubmed:year1977lld:pubmed
pubmed-article:190222pubmed:articleTitleRelative importance of 7-methylguanosine in ribosome binding and translation of vesicular stomatitis virus mRNA in wheat germ and reticulocyte cell-free systems.lld:pubmed
pubmed-article:190222pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:190222pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:190222lld:pubmed