| pubmed-article:1901894 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1901894 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:1901894 | lifeskim:mentions | umls-concept:C2337419 | lld:lifeskim |
| pubmed-article:1901894 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:1901894 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:1901894 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:1901894 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1901894 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1901894 | pubmed:dateCreated | 1991-5-23 | lld:pubmed |
| pubmed-article:1901894 | pubmed:abstractText | Macrophages are important regulatory cells that can both stimulate and down-regulate various immune functions. During syphilitic infection, these cells phagocytize, kill, and lyse Treponema pallidum. They also modulate early T cell activation by decreasing IL-2 production through secretion of PG. This report focuses on additional complexities of macrophage regulation. Non-adherent splenic cells were stimulated with Con A to induce IFN-gamma synthesis. High levels were detected in preparations from normal rabbits and much lower levels in preparations from infected rabbits. The organisms also readily stimulated IL-1 synthesis by adherent spleen preparations from normal but not from infected rabbits. When indomethacin was added to these latter preparations, this IL-1 defect was reversed, implicating PG in this down-regulation. Spleen cells were obtained from normal rabbits and from rabbits infected testicularly for 9 to 12 days. Infection elevated basal levels of class II Ia Ag on adherent cells. In addition, macrophage Ia expression was increased during 4 days of in vitro incubation with treponemes. Non-adherent spleen cells from infected animals inhibited two different macrophage functions. First, culture filtrates obtained after 48 h of incubation contained a soluble factor that subsequently decreased LPS-induced IL-1 synthesis. Second, when macrophages were co-incubated with non-adherent cells, treponemal stimulation of macrophage Ia expression was inhibited; this inhibition was reversed by indomethacin implicating prostaglandins in this down-regulation. In further experiments an exogenous source of IFN-gamma was incubated with adherent cells from infected rabbits. This stimulated macrophage function as shown by increased IL-1 synthesis and Ia expression and decreased PGE2 secretion. Results are discussed in terms of the complexities of immunoregulation by macrophages during syphilitic infection. | lld:pubmed |
| pubmed-article:1901894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1901894 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1901894 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1901894 | pubmed:month | May | lld:pubmed |
| pubmed-article:1901894 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1901894 | pubmed:author | pubmed-author:FitzgeraldT... | lld:pubmed |
| pubmed-article:1901894 | pubmed:author | pubmed-author:TomaiM AMA | lld:pubmed |
| pubmed-article:1901894 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1901894 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1901894 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1901894 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1901894 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1901894 | pubmed:pagination | 3171-6 | lld:pubmed |
| pubmed-article:1901894 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1901894 | pubmed:meshHeading | pubmed-meshheading:1901894-... | lld:pubmed |
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| pubmed-article:1901894 | pubmed:meshHeading | pubmed-meshheading:1901894-... | lld:pubmed |
| pubmed-article:1901894 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1901894 | pubmed:articleTitle | Splenic macrophage function in early syphilitic infection is complex. Stimulation versus down-regulation. | lld:pubmed |
| pubmed-article:1901894 | pubmed:affiliation | Department of Medical Microbiology and Immunology, School of Medicine, University of Minnesota, Duluth 55812. | lld:pubmed |
| pubmed-article:1901894 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1901894 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1901894 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1901894 | lld:pubmed |
