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pubmed-article:19018277pubmed:abstractTextA great deal of sub-cellular organelle positioning, and essentially all minus-ended organelle transport, depends on cytoplasmic dynein, but how dynein's function is regulated is not well understood. BicD is established to play a critical role in mediating dynein function-loss of BicD results in improperly localized nuclei, mRNA particles, and a dispersed Golgi apparatus-however exactly what BicD's role is remains unknown. Nonetheless, it is widely believed that BicD may act to tether dynein to cargos. Here we use a combination of biophysical and biochemical studies to investigate BicD's role in lipid droplet transport during Drosophila embryogenesis.lld:pubmed
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pubmed-article:19018277pubmed:articleTitleBicaudalD actively regulates microtubule motor activity in lipid droplet transport.lld:pubmed
pubmed-article:19018277pubmed:affiliationDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, California, USA.lld:pubmed
pubmed-article:19018277pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19018277pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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