| pubmed-article:19018242 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0086282 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0334583 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0205422 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C1550594 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0752248 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0538135 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C1538259 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C1548760 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C1547300 | lld:lifeskim |
| pubmed-article:19018242 | lifeskim:mentions | umls-concept:C0580822 | lld:lifeskim |
| pubmed-article:19018242 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19018242 | pubmed:dateCreated | 2008-12-8 | lld:pubmed |
| pubmed-article:19018242 | pubmed:abstractText | Pilocytic astrocytomas (PAs) are World Health Organization Grade I gliomas; they most often affect children and young adults and occur in patients with neurofibromatosis type 1 (NF1). To identify genes that are differentially expressed in sporadic (S-PA) versus NF1-associated PAs (NF1-PAs) and those that might reflect differences in clinical behavior, we performed gene expression profiling using Affymetrix U133 Plus2.0 GeneChip arrays in 36 S-PAs and 11 NF1-PAs. Thirteen genes were overexpressed, and another 13 genes were underexpressed in NF1-PAs relative to S-PAs. Immunohistochemical studies performed on 103 tumors, representing 2 independently generated tissue microarrays, confirmed the differential expression of CUGBP2 (p = 0.0014), RANBP9 (p = 0.0075), ITGAV1 (p = 0.0001), and INFGR1 (p = 0.024) proteins. One of the underexpressed genes, aldehyde dehydrogenase 1 family member L1 (ALDH1L1), was also reduced in clinically aggressive compared with typical PAs (p = 0.01) and in PAs with increased cellularity and necrosis. Furthermore, in an additional independent set of tumors, weak to absent ALDH1L1 expression was found in 13 (72%) of 18 clinically aggressive PAs, in 8 (89%) of 9 PAs with pilomyxoid features, in 7 (70%) of 10 PAs with anaplastic transformation, and in 16 (76%) of 21 diffusely infiltrating astrocytomas of various grades. In summary, we have identified a molecular signature that distinguishes NF1-PA from S-PA and found that ALDH1L1 underexpression is associated with aggressive histology and/or biologic behavior. | lld:pubmed |
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| pubmed-article:19018242 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19018242 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19018242 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19018242 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19018242 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19018242 | pubmed:issn | 0022-3069 | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:AnantShrikant... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:SarkariaJann... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:EberhartCharl... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:PerryArieA | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:JenkinsRobert... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:ScheithauerBe... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:GutmannDavid... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:GianniniCater... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:AsmannYan WYW | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:SharmaMukesh... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:JenkinsSarahS | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:RodriguezFaus... | lld:pubmed |
| pubmed-article:19018242 | pubmed:author | pubmed-author:TibbettsKathl... | lld:pubmed |
| pubmed-article:19018242 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19018242 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:19018242 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19018242 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19018242 | pubmed:pagination | 1194-204 | lld:pubmed |
| pubmed-article:19018242 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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