Linked Life Data

19013820

Source:http://linkedlifedata.com/resource/pubmed/id/19013820

Statements in which the resource exists.
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pubmed-article:19013820pubmed:abstractTextA series of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives were synthesized by the reaction of ethyl 3-aryl-1-(2-bromoethyl)-1H-pyrazole-5-carboxylate and amine in the general heating condition and microwave-assisted condition. The structures of the compounds were determined by IR, (1)H NMR and mass spectroscopy, in addition, representative single-crystal structures were characterized by using X-ray diffraction analysis. Preliminary biological evaluation showed that the compounds could inhibit the growth of A549 cells in dosage- and time-dependent manners. The study on structure-activity relationships showed that compounds with 4-chlorophenyl group at pyrazole moiety, such as 5-benzyl-2-(4-chlorophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (3o) had much more inhibitory effects. Compound 3o was the most effective small molecule in inhibiting A549 cell growth and might perform its action through modulating autophagy.lld:pubmed
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pubmed-article:19013820pubmed:articleTitleSynthesis and preliminary biological evaluation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells.lld:pubmed
pubmed-article:19013820pubmed:affiliationInstitute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.lld:pubmed
pubmed-article:19013820pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19013820pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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