| pubmed-article:1900952 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C1536403 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C0221117 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C1819447 | lld:lifeskim |
| pubmed-article:1900952 | lifeskim:mentions | umls-concept:C1534709 | lld:lifeskim |
| pubmed-article:1900952 | pubmed:issue | 4998 | lld:pubmed |
| pubmed-article:1900952 | pubmed:dateCreated | 1991-4-23 | lld:pubmed |
| pubmed-article:1900952 | pubmed:abstractText | Engagement of the antigen-specific receptor (TCR) of CD4+ T lymphocytes without a second (costimulatory) signal prevents the subsequent production of interleukin-2 (IL-2) by these cells. Because IL-2 is a key immunoregulatory lymphokine and is also produced by a subset of CD8+ T cells that are able to kill target cells, the effect of engaging the TCR of one such clone in the absence of costimulatory signals was examined. The capacity for TCR-dependent IL-2 production was lost, indicating comparable costimulator-dependent signaling requirements for IL-2 production in CD4+ and CD8+ T cells. However, TCR-mediated cytotoxicity was not impaired, implying that costimulation is required for only certain TCR-dependent effector functions. | lld:pubmed |
| pubmed-article:1900952 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1900952 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900952 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1900952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1900952 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900952 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1900952 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1900952 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:1900952 | pubmed:author | pubmed-author:GermainR NRN | lld:pubmed |
| pubmed-article:1900952 | pubmed:author | pubmed-author:OttenG RGR | lld:pubmed |
| pubmed-article:1900952 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1900952 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:1900952 | pubmed:volume | 251 | lld:pubmed |
| pubmed-article:1900952 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1900952 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1900952 | pubmed:pagination | 1228-31 | lld:pubmed |
| pubmed-article:1900952 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:1900952 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1900952 | pubmed:articleTitle | Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. | lld:pubmed |
| pubmed-article:1900952 | pubmed:affiliation | Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:1900952 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1900952 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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