| pubmed-article:19004999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0013343 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0392918 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0038128 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0449243 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C2825050 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C1547008 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C1522605 | lld:lifeskim |
| pubmed-article:19004999 | lifeskim:mentions | umls-concept:C1268822 | lld:lifeskim |
| pubmed-article:19004999 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19004999 | pubmed:dateCreated | 2009-1-14 | lld:pubmed |
| pubmed-article:19004999 | pubmed:abstractText | Physiological activity of the turtle cerebellar cortex (Cb), maintained in vitro, was recorded during microstimulation of inferior olive (IO). Previous single-electrode responses to such stimulation showed similar latencies across a limited region of Cb, yet those recordings lacked spatial and temporal resolution and the recording depth was variable. The topography and timing of those responses were reexamined using photodiode optical recordings. Because turtle Cb is thin and unfoliated, its entire surface can be stained by a voltage-sensitive dye and transilluminated to measure changes in its local absorbance. Microstimulation of the IO evoked widespread depolarization from the rostral to the caudal edge of the contralateral Cb. The time course of responses measured at a single photodiode matched that of single-microelectrode responses in the corresponding Cb locus. The largest and most readily evoked response was a sagittal band centered about 0.7 mm from the midline. Focal white-matter (WM) microstimulation on the ventricular surface also activated sagittal bands, whereas stimulation of adjacent granule cells evoked a radial patch of activation. In contrast, molecular-layer (ML) microstimulation evoked transverse beams of activation, centered on the rostrocaudal stimulus position, which traveled bidirectionally across the midline to the lateral edges of the Cb. A timing analysis demonstrated that both IO and WM microstimulation evoked responses with a nearly simultaneous onset along a sagittal band, whereas ML microstimulation evoked a slowly propagating wave traveling about 25 cm/s. The response similarity to IO and WM microstimulation suggests that the responses to WM microstimulation are dominated by activation of its climbing fibers. The Cb's role in the generation of precise motor control may result from these temporal and topographic differences in orthogonally oriented pathways. Optical recordings of the turtle's thin flat Cb can provide insights into that role. | lld:pubmed |
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| pubmed-article:19004999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19004999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004999 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19004999 | pubmed:status | MEDLINE | lld:pubmed |
