| pubmed-article:19004955 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19004955 | lifeskim:mentions | umls-concept:C0019351 | lld:lifeskim |
| pubmed-article:19004955 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:19004955 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:19004955 | lifeskim:mentions | umls-concept:C1749719 | lld:lifeskim |
| pubmed-article:19004955 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19004955 | pubmed:dateCreated | 2008-12-30 | lld:pubmed |
| pubmed-article:19004955 | pubmed:abstractText | Interleukin-15 (IL-15) is necessary for the development and function of NK/NKT cells and the maintenance of naive and memory CD8(+) T cells. In the absence of IL-15, protective innate immunity is not available; however, a functional adaptive immune response against vaginal herpes simplex virus 2 (HSV-2) is generated. Mice overexpressing IL-15 (IL-15tg mice) have higher numbers of NK cells, greater NK-derived gamma interferon, and more CD8(+) T cells. Here we examined the consequences of IL-15 overexpression for innate and adaptive immunity against genital HSV-2. Surprisingly, IL-15tg mice immunized against HSV-2 were not protected against genital HSV-2 challenge compared to control immunized mice. IL-15tg mice had a higher frequency of NK cells in the genital mucosa than control mice. However, immunized IL-15tg mice had significantly lower numbers of HSV-2-specific CD4(+) T cells than B6 mice. We then confirmed that CD4(+) T cells, but not CD8(+) T cells, are essential for protection against intravaginal HSV-2 challenge. Since we observed less protection in immunized IL-15tg mice, we then examined if the adaptive immune responses generated in an environment with overexpression of IL-15 could provide protection against HSV-2 in an environment with normal levels of IL-15 expression. We adoptively transferred immunized cells from IL-15tg and B6 mice into naive RAG-1(-/-) mice and found that the cells from immunized IL-15tg mice were able to provide protection in this IL-15-normal environment. Our data suggest that overexpression of IL-15 results in a reduced CD4(+) T cell-mediated adaptive immune response against genital HSV-2. | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19004955 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19004955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19004955 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19004955 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19004955 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:19004955 | pubmed:author | pubmed-author:AshkarAli AAA | lld:pubmed |
| pubmed-article:19004955 | pubmed:author | pubmed-author:GillNavkiranN | lld:pubmed |
| pubmed-article:19004955 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19004955 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:19004955 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19004955 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19004955 | pubmed:pagination | 918-26 | lld:pubmed |
| pubmed-article:19004955 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:19004955 | pubmed:meshHeading | pubmed-meshheading:19004955... | lld:pubmed |
| pubmed-article:19004955 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19004955 | pubmed:articleTitle | Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2. | lld:pubmed |
| pubmed-article:19004955 | pubmed:affiliation | Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:19004955 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19004955 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16168 | entrezgene:pubmed | pubmed-article:19004955 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19004955 | lld:entrezgene |
