pubmed-article:19002177 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0302592 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
pubmed-article:19002177 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:19002177 | pubmed:issue | 10 | lld:pubmed |
pubmed-article:19002177 | pubmed:dateCreated | 2008-11-12 | lld:pubmed |
pubmed-article:19002177 | pubmed:abstractText | The ID protein, an inhibitor of basic helix-loop-helix (HLH) transcription factors, has been involved in multiple cellular processes. To investigate the association between tumour advancement and ID expressions of uterine cervical cancers, the levels of ID-1, ID-2 and ID-3 mRNAs were determined by real-time reverse transcription-polymerase chain reaction and the histoscore with the localisation of ID-1 was determined by immunohistochemistry and patient survival in 60 patients. ID-1 histoscores and mRNA levels both significantly (P<0.05) increased in uterine cervical cancers according to clinical stage regardless of histopathological type or lymph node metastasis. Furthermore, the 36-month survival rate of the 30 patients with high ID-1 was poor (60%), whereas that of the other 30 patients with low ID-1 was significantly higher (83%). ID-1 histoscores and mRNA levels significantly (P<0.0001) correlated with microvessel counts in uterine cervical cancers. Tumour cells show mostly diffuse to strong cytoplasmic expression of ID-1 and also very faint expression in endothelial cells. Moreover, ID-1 expression not only correlated with microvessel counts but also correlated significantly with histoscore. Therefore, ID-1 might work on tumour advancement through angiogenic activity and is considered to be a candidate for a prognostic indicator in uterine cervical cancers. | lld:pubmed |
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pubmed-article:19002177 | pubmed:language | eng | lld:pubmed |
pubmed-article:19002177 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19002177 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:19002177 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19002177 | pubmed:month | Nov | lld:pubmed |
pubmed-article:19002177 | pubmed:issn | 1532-1827 | lld:pubmed |
pubmed-article:19002177 | pubmed:author | pubmed-author:FujimotoJJ | lld:pubmed |
pubmed-article:19002177 | pubmed:author | pubmed-author:TamayaTT | lld:pubmed |
pubmed-article:19002177 | pubmed:author | pubmed-author:HewH YHY | lld:pubmed |
pubmed-article:19002177 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19002177 | pubmed:day | 18 | lld:pubmed |
pubmed-article:19002177 | pubmed:volume | 99 | lld:pubmed |
pubmed-article:19002177 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19002177 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19002177 | pubmed:pagination | 1557-63 | lld:pubmed |
pubmed-article:19002177 | pubmed:dateRevised | 2010-9-23 | lld:pubmed |
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pubmed-article:19002177 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:19002177 | pubmed:articleTitle | Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers. | lld:pubmed |
pubmed-article:19002177 | pubmed:affiliation | Department of Obstetrics and Gynecology, Graduate School of Medicine, Gifu University School of Medicine, Gifu City, Japan. | lld:pubmed |
pubmed-article:19002177 | pubmed:publicationType | Journal Article | lld:pubmed |
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