| pubmed-article:19000725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19000725 | lifeskim:mentions | umls-concept:C1563732 | lld:lifeskim |
| pubmed-article:19000725 | lifeskim:mentions | umls-concept:C1706211 | lld:lifeskim |
| pubmed-article:19000725 | lifeskim:mentions | umls-concept:C0920425 | lld:lifeskim |
| pubmed-article:19000725 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19000725 | lifeskim:mentions | umls-concept:C0070971 | lld:lifeskim |
| pubmed-article:19000725 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19000725 | pubmed:dateCreated | 2009-1-27 | lld:pubmed |
| pubmed-article:19000725 | pubmed:abstractText | Photodynamic therapy (PDT) is a promising method for the localized treatment of solid tumors. In order to enhance the efficacy of PDT, we have recently developed a novel class of photosensitizer formulation, i.e., the dendrimer phthalocyanine (DPc)-encapsulated polymeric micelle (DPc/m). The DPc/m induced efficient and unprecedentedly rapid cell death accompanied by characteristic morphological changes such as blebbing of cell membranes, when the cells were photoirradiated using a low power halogen lamp or a high power diode laser. The fluorescent microscopic observation using organelle-specific dyes demonstrated that DPc/m might accumulate in the endo-/lysosomes; however, upon photoirradiation, DPc/m might be promptly released into the cytoplasm and photodamage the mitochondria, which may account for the enhanced photocytotoxicity of DPc/m. This study also demonstrated that DPc/m showed significantly higher in vivo PDT efficacy than clinically used Photofrin (polyhematoporphyrin esters, PHE) in mice bearing human lung adenocarcinoma A549 cells. Furthermore, the DPc/m-treated mice did not show skin phototoxiciy, which was apparently observed for the PHE-treated mice, under the tested conditions. These results strongly suggest the usefulness of DPc/m in clinical PDT. | lld:pubmed |
| pubmed-article:19000725 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19000725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19000725 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19000725 | pubmed:issn | 1873-4995 | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:MiyazakiKozoK | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:KikuchiMakoto... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:NishiyamaNobu... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:MorimotoYujiY | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:KataokaKazuno... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:YuChengC | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:HorieSoutaS | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:FukushimaShig... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:JangWoo-DongW... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:NakagishiYosh... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:LaiPing-ShanP... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:KumagaiMichia... | lld:pubmed |
| pubmed-article:19000725 | pubmed:author | pubmed-author:UranoKyokoK | lld:pubmed |
| pubmed-article:19000725 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19000725 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:19000725 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:19000725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19000725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19000725 | pubmed:pagination | 245-51 | lld:pubmed |
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| pubmed-article:19000725 | pubmed:meshHeading | pubmed-meshheading:19000725... | lld:pubmed |
| pubmed-article:19000725 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19000725 | pubmed:articleTitle | Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine. | lld:pubmed |
| pubmed-article:19000725 | pubmed:affiliation | Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:19000725 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19000725 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19000725 | lld:pubmed |
