| pubmed-article:1899686 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1899686 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:1899686 | lifeskim:mentions | umls-concept:C1955941 | lld:lifeskim |
| pubmed-article:1899686 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:1899686 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1899686 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:1899686 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1899686 | pubmed:dateCreated | 1991-3-19 | lld:pubmed |
| pubmed-article:1899686 | pubmed:abstractText | The maturation potential of CD4-8- thymocytes purified from mice of different developmental ages was examined in vivo after intrathymic injection. As previously reported, 14-day fetal CD4-8- thymocytes produced fewer CD4+ than CD8+ progeny in peripheral lymphoid tissues, resulting in a CD4+:CD8+ ratio of less than or equal to 1.0. In contrast, adult CD4-8- thymocytes generated CD4+ or CD8+ peripheral progeny in the proportions found in the normal adult animal (CD4+:CD8+ = 2 to 3). Here we have shown that CD4-8- precursor cells from the 17-day fetal thymus also produced peripheral lymphocytes with low CD4+:CD8+ ratios. Precursors from full term fetuses produced slightly higher CD4+:CD8+ ratios (1.1-1.6) and precursors from animals three to 4 days post-birth achieved CD4+:CD8+ ratios intermediate between those produced by fetal and adult CD4-8- thymocytes. Parallel changes in the production of alpha beta TCR+ peripheral progeny were observed. Fetal CD4-8- thymocytes generated fewer alpha beta TCR+ progeny than did adult CD4-8- thymocytes. However, peripheral lymphocytes arising from either fetal or adult thymic precursors showed similar proportions of gamma delta TCR+ cells. The same pattern of progeny was observed when fetal CD4-8- thymocytes matured in an adult or in a fetal thymic stromal environment. In contrast to fetal thymic precursors, fetal liver T cell precursors resembled adult CD4-8- thymocytes by all parameters measured. These results suggest that fetal thymic precursors are intrinsically different from both adult CD4-8- thymocytes and fetal liver T cell precursors. Moreover, they lead to the hypothesis that the composition of the peripheral T cell compartment is developmentally regulated by the types of precursors found in the thymus. A model is proposed in which migration of adult-like precursors from the fetal liver to the thymus approximately at birth triggers a transition from the fetal to the adult stages of intrathymic T cell differentiation. | lld:pubmed |
| pubmed-article:1899686 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1899686 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1899686 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1899686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1899686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1899686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1899686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1899686 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1899686 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1899686 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1899686 | pubmed:author | pubmed-author:AdkinsBB | lld:pubmed |
| pubmed-article:1899686 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1899686 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1899686 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1899686 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1899686 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1899686 | pubmed:pagination | 1387-93 | lld:pubmed |
| pubmed-article:1899686 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1899686 | pubmed:meshHeading | pubmed-meshheading:1899686-... | lld:pubmed |
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| pubmed-article:1899686 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1899686 | pubmed:articleTitle | Developmental regulation of the intrathymic T cell precursor population. | lld:pubmed |
| pubmed-article:1899686 | pubmed:affiliation | Department of Pathology, University of Miami Medical School, FL 33136. | lld:pubmed |
| pubmed-article:1899686 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1899686 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1899686 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1899686 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1899686 | lld:pubmed |
