Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18992284rdf:typepubmed:Citationlld:pubmed
pubmed-article:18992284lifeskim:mentionsumls-concept:C0330390lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0379710lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0017636lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0001807lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0021701lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C2003941lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0231491lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C2587213lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C1741686lld:lifeskim
pubmed-article:18992284lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:18992284pubmed:issue2lld:pubmed
pubmed-article:18992284pubmed:dateCreated2009-1-26lld:pubmed
pubmed-article:18992284pubmed:abstractTextCaveolin-1 plays a checkpoint function in the regulation of processes often altered in cancer. Although increased expression of caveolin-1 seems to be the norm in the glioma family of malignancies, populations of caveolin-1 positive and negative cells coexist among glioblastoma specimens. As no data are available to date on the contribution of such cells to the phenotype of glioblastoma, we manipulated caveolin-1 in the glioblastoma cell line U87MG. We showed that caveolin-1 plays a critical role in the aggressiveness of glioblastoma. We identified integrins as the main set of genes affected by caveolin-1. We reported here that the phenotypic changes observed after caveolin-1 modulation were mediated by alpha(5)beta(1) integrins. As a consequence of the regulation of alpha(5)beta(1) levels by caveolin-1, the sensitivity of cells to the specific alpha(5)beta(1) integrin antagonist, SJ749, was affected. Mediator of caveolin-1 effects, alpha(5)beta(1) integrin, is also a marker for glioma aggressiveness and an efficient target for the treatment of glioma especially the ones exerting the highest aggressive phenotype.lld:pubmed
pubmed-article:18992284pubmed:languageenglld:pubmed
pubmed-article:18992284pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:citationSubsetIMlld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18992284pubmed:statusMEDLINElld:pubmed
pubmed-article:18992284pubmed:monthFeblld:pubmed
pubmed-article:18992284pubmed:issn0006-3002lld:pubmed
pubmed-article:18992284pubmed:authorpubmed-author:DontenwillMon...lld:pubmed
pubmed-article:18992284pubmed:authorpubmed-author:TakedaKenKlld:pubmed
pubmed-article:18992284pubmed:authorpubmed-author:MartinSophieSlld:pubmed
pubmed-article:18992284pubmed:authorpubmed-author:TerrandJérôme...lld:pubmed
pubmed-article:18992284pubmed:authorpubmed-author:MaglottAnneAlld:pubmed
pubmed-article:18992284pubmed:authorpubmed-author:CossetErika...lld:pubmed
pubmed-article:18992284pubmed:issnTypePrintlld:pubmed
pubmed-article:18992284pubmed:volume1793lld:pubmed
pubmed-article:18992284pubmed:ownerNLMlld:pubmed
pubmed-article:18992284pubmed:authorsCompleteYlld:pubmed
pubmed-article:18992284pubmed:pagination354-67lld:pubmed
pubmed-article:18992284pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:meshHeadingpubmed-meshheading:18992284...lld:pubmed
pubmed-article:18992284pubmed:year2009lld:pubmed
pubmed-article:18992284pubmed:articleTitleCaveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist.lld:pubmed
pubmed-article:18992284pubmed:affiliationUniversité Strasbourg 1 Institut Gilbert Laustriat, CNRS UMR 7175, Illkirch, France. Sophie.Martin@pharma.u-strasbg.frlld:pubmed
pubmed-article:18992284pubmed:publicationTypeJournal Articlelld:pubmed
entrez-gene:857entrezgene:pubmedpubmed-article:18992284lld:entrezgene
entrez-gene:3678entrezgene:pubmedpubmed-article:18992284lld:entrezgene
entrez-gene:3688entrezgene:pubmedpubmed-article:18992284lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:18992284lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:18992284lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:18992284lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18992284lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18992284lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18992284lld:pubmed