| pubmed-article:18981164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0017890 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C1414557 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C0349590 | lld:lifeskim |
| pubmed-article:18981164 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:18981164 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18981164 | pubmed:dateCreated | 2008-11-4 | lld:pubmed |
| pubmed-article:18981164 | pubmed:abstractText | Detailed assessment of how the structural properties of T cell receptors affect clonal repertoires of Ag-specific cells is a prerequisite for a better understanding of human antiviral immunity. Herein we examine the alpha TCR repertoires of CD8 T cells reactive against the influenza A viral epitope M1(58-66), restricted by HLA-A2.1. Using molecular cloning, we systematically studied the impact of alpha-chain usage in the formation of T cell memory and revealed that M1(58-66)-specific, clonally diverse VB19 T cells express alpha-chains encoded by multiple AV genes with different CDR3 sizes. A unique feature of these alpha TCRs was the presence of CDR3 fitting to an AGA(G(n))GG-like amino acid motif. This pattern was consistent over time and among different individuals. Further molecular assessment of human CD4(+)CD8(-) and CD4(-)CD8(+) thymocytes led to the conclusion that the poly-Gly/Ala runs in CDR3alpha were a property of immune, but not naive, repertoires and could be attributed to influenza exposure. Repertoires of T cell memory are discussed in the context of clonal diversity, where poly-Gly/Ala runs in the CDR3 of alpha- and beta-chains might provide high levels of TCR flexibility during Ag recognition while gene-encoded CDR1 and CDR2 contribute to the fine specificity of the TCR-peptide MHC interaction. | lld:pubmed |
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| pubmed-article:18981164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18981164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18981164 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18981164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18981164 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18981164 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:18981164 | pubmed:author | pubmed-author:WelshRaymond... | lld:pubmed |
| pubmed-article:18981164 | pubmed:author | pubmed-author:SelinLiisa... | lld:pubmed |
| pubmed-article:18981164 | pubmed:author | pubmed-author:NaumovYuri... | lld:pubmed |
| pubmed-article:18981164 | pubmed:author | pubmed-author:NaumovaElena... | lld:pubmed |
| pubmed-article:18981164 | pubmed:author | pubmed-author:KotaKalyaniK | lld:pubmed |
| pubmed-article:18981164 | pubmed:author | pubmed-author:YassaiMaryam... | lld:pubmed |
| pubmed-article:18981164 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18981164 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18981164 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:18981164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18981164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18981164 | pubmed:pagination | 7407-19 | lld:pubmed |
| pubmed-article:18981164 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
