| pubmed-article:1897947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C0007301 | lld:lifeskim |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C0033692 | lld:lifeskim |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C0728907 | lld:lifeskim |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1897947 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:1897947 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1897947 | pubmed:dateCreated | 1991-10-24 | lld:pubmed |
| pubmed-article:1897947 | pubmed:abstractText | The effects of mechanical compression of calf cartilage explants on the catabolism and loss into the medium of proteoglycans and proteins radiolabeled with [35S]sulfate and [3H]proline were examined. A single 2- or 12-h compression of 3-mm diameter cartilage disks from a thickness of 1.25 to 0.50 mm, or slow cyclic compression (2 h on/2 h off) from 1.25 mm to 1.00, 0.75, or 0.50 mm for 24 h led to transient alterations and/or sustained increases in loss of radiolabeled macromolecules. The effects of imposing or removing loads were consistent with several compression-induced physical mediators including fluid flow, diffusion, and matrix disruption. Cyclic compression induced convective fluid flow and enhanced the loss of 35S- and 3H-labeled macromolecules from tissue into medium. In contrast, prolonged static compression induced matrix consolidation and appeared to hinder the diffusional transport and loss of 35S- and 3H-labeled macromolecules. Since high amplitude cyclic compression led to a sustained increase in the rate of loss of 3H- and 35S-labeled macromolecules that was accompanied by an increase in the rate of loss of [3H]hydroxyproline residues and an increase in tissue hydration, such compression may have caused disruption of the collagen meshwork. The 35S-labeled proteoglycans lost during such cyclic compression were of smaller average size than those from controls, but contained a similarly low proportion (approximately 15%) that could form aggregates with excess hyaluronate and link protein. The size distribution and aggregability of the remaining tissue proteoglycans and 35S-labeled proteoglycans were not markedly affected. The loss of tissue proteoglycan paralleled the loss of 35S-labeled macromolecules. This study provides a framework for elucidating the biophysical mechanisms involved in the redistribution, catabolism, and loss of macromolecules during cartilage compression. | lld:pubmed |
| pubmed-article:1897947 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1897947 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1897947 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1897947 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1897947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1897947 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1897947 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:1897947 | pubmed:author | pubmed-author:SandsJ JJJ | lld:pubmed |
| pubmed-article:1897947 | pubmed:author | pubmed-author:GrodzinskyA... | lld:pubmed |
| pubmed-article:1897947 | pubmed:author | pubmed-author:LIUY CYC | lld:pubmed |
| pubmed-article:1897947 | pubmed:author | pubmed-author:PlaasA HAH | lld:pubmed |
| pubmed-article:1897947 | pubmed:author | pubmed-author:DoongJ YJY | lld:pubmed |
| pubmed-article:1897947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1897947 | pubmed:volume | 286 | lld:pubmed |
| pubmed-article:1897947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1897947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1897947 | pubmed:pagination | 20-9 | lld:pubmed |
| pubmed-article:1897947 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1897947 | pubmed:meshHeading | pubmed-meshheading:1897947-... | lld:pubmed |
| pubmed-article:1897947 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1897947 | pubmed:articleTitle | Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants. | lld:pubmed |
| pubmed-article:1897947 | pubmed:affiliation | Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology & Harvard-M.I.T., Cambridge. | lld:pubmed |
| pubmed-article:1897947 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1897947 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1897947 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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