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pubmed-article:1896511pubmed:abstractTextEntrained and free-running rhythms of wheel-running activity were recorded in male BALB/cByJ mice with electrolytic lesions of the suprachiasmatic nucleus (SCN), site of a circadian pacemaker in mammals. Complete ablation of the nucleus abolished the circadian locomotor rhythm; in some cases, wheel-running was synchronized by a light-dark cycle, but the phase relationship of this activity to the cycle was often aberrant. Unilateral lesions or those missing the SCN did not eliminate rhythmicity.lld:pubmed
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pubmed-article:1896511pubmed:articleTitleLesions of the suprachiasmatic nucleus disrupt circadian locomotor rhythms in the mouse.lld:pubmed
pubmed-article:1896511pubmed:affiliationDepartment of Neurology, University of Massachusetts Medical School, Worcester 01655.lld:pubmed
pubmed-article:1896511pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1896511pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed