| pubmed-article:1896091 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0041948 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C1819447 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1896091 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1896091 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1896091 | pubmed:dateCreated | 1991-10-24 | lld:pubmed |
| pubmed-article:1896091 | pubmed:abstractText | We have studied the role of interleukin-2 (IL-2) and its receptors in the impaired in vitro lymphocyte response characteristic of hemodialysis patients treated by means of cuprophane membranes. The proliferative response of T lymphocytes as well as T-cell-dependent B cell proliferation after stimulation with mitogens was significantly reduced in hemodialysis patients. The in vitro production of IL-2 after such stimulation in parallel cultures was found to be similar in patients and in controls. The expression of IL-2 receptor on the lymphocyte cellular membrane in the hemodialysis group was also similar to controls. The in vitro proliferative response of uremic lymphocytes to exogenous IL-2, however, was significantly depressed suggesting a reduced availability of biologically active IL-2 receptor. The release of soluble IL-2 receptor by lectin-stimulated lymphocytes in culture was also significantly lower in the patient group; yet, hemodialysis patients has a strikingly elevated level of plasma soluble IL-2 receptor, and similar high levels were also found in three other groups of end-stage renal disease patients dialyzed by means of cellulose acetate, polysulfone and polyacrylonitrile membranes, as well as in a group of uremic patients on conservative treatment. In the hemodialysis patient group a significant positive correlation between levels of soluble IL-2 receptor and the duration of hemodialysis was found. Since soluble IL-2 receptor has been reported to down-regulate lymphocyte responses, the elevation in plasma levels of soluble IL-2 receptor in hemodialysis patients may be a pathogenetic factor in the progressive development of impaired immunity associated with end-stage renal disease. | lld:pubmed |
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| pubmed-article:1896091 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1896091 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1896091 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1896091 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1896091 | pubmed:issn | 0028-2766 | lld:pubmed |
| pubmed-article:1896091 | pubmed:author | pubmed-author:RaskovaJJ | lld:pubmed |
| pubmed-article:1896091 | pubmed:author | pubmed-author:GastaldiLL | lld:pubmed |
| pubmed-article:1896091 | pubmed:author | pubmed-author:RaskaKKJr | lld:pubmed |
| pubmed-article:1896091 | pubmed:author | pubmed-author:DonathEE | lld:pubmed |
| pubmed-article:1896091 | pubmed:author | pubmed-author:HomerLL | lld:pubmed |
| pubmed-article:1896091 | pubmed:author | pubmed-author:DegiannisDD | lld:pubmed |
| pubmed-article:1896091 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1896091 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:1896091 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1896091 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1896091 | pubmed:pagination | 268-75 | lld:pubmed |
| pubmed-article:1896091 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1896091 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1896091 | pubmed:articleTitle | Immune deficiency in uremia: interleukin-2 production and responsiveness and interleukin-2 receptor expression and release. | lld:pubmed |
| pubmed-article:1896091 | pubmed:affiliation | Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway. | lld:pubmed |
| pubmed-article:1896091 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1896091 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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