| pubmed-article:18952059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18952059 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18952059 | lifeskim:mentions | umls-concept:C0037868 | lld:lifeskim |
| pubmed-article:18952059 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:18952059 | lifeskim:mentions | umls-concept:C1825632 | lld:lifeskim |
| pubmed-article:18952059 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18952059 | pubmed:dateCreated | 2008-11-25 | lld:pubmed |
| pubmed-article:18952059 | pubmed:abstractText | IZUMO is the mouse sperm protein proven to be essential for fusion with eggs. It contains one immunoglobulin-like domain with a conserved glycosylation site within. In the present paper, we produced transgenic mouse lines expressing unglycosylated IZUMO (N204Q-IZUMO) in Izumo1 -/- background. The expression of N204Q-IZUMO rescued the infertile phenotype of IZUMO disrupted mice, indicating glycosylation is not essential for fusion-facilitating activity of IZUMO. The N204Q-IZUMO was produced in testis in comparable amounts to wild-type IZUMO, but the amount of N204Q-IZUMO on sperm was significantly decreased by the time sperm reached the cauda epididymis. These data suggest that glycosylation is not essential for the function of IZUMO, but has a role in protecting it from fragmentation in cauda epididymis. | lld:pubmed |
| pubmed-article:18952059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18952059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18952059 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18952059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18952059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18952059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18952059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18952059 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18952059 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18952059 | pubmed:author | pubmed-author:OkabeMasaruM | lld:pubmed |
| pubmed-article:18952059 | pubmed:author | pubmed-author:IkawaMasahito... | lld:pubmed |
| pubmed-article:18952059 | pubmed:author | pubmed-author:InoueNaokazuN | lld:pubmed |
| pubmed-article:18952059 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18952059 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:18952059 | pubmed:volume | 377 | lld:pubmed |
| pubmed-article:18952059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18952059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18952059 | pubmed:pagination | 910-4 | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:meshHeading | pubmed-meshheading:18952059... | lld:pubmed |
| pubmed-article:18952059 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18952059 | pubmed:articleTitle | Putative sperm fusion protein IZUMO and the role of N-glycosylation. | lld:pubmed |
| pubmed-article:18952059 | pubmed:affiliation | Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:18952059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18952059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://bio2rdf.org/pubmed:1... | skos:relatedMatch | pubmed-article:18952059 | lld:mappings |
| entrez-gene:284359 | entrezgene:pubmed | pubmed-article:18952059 | lld:entrezgene |
| entrez-gene:73456 | entrezgene:pubmed | pubmed-article:18952059 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18952059 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18952059 | lld:pubmed |
