| pubmed-article:18950955 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18950955 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:18950955 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18950955 | lifeskim:mentions | umls-concept:C0221910 | lld:lifeskim |
| pubmed-article:18950955 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:18950955 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:18950955 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18950955 | pubmed:dateCreated | 2009-3-13 | lld:pubmed |
| pubmed-article:18950955 | pubmed:abstractText | It is well known that induction of immunotolerance with allogeneic skin transplantation is generally difficult. This study attempted to find an immunosuppressive protocol for skin allograft rejection involving interleukin-16 (IL-16) and interleukin-10 (IL-10), because both are known to inhibit mixed lymphocyte reaction (MLR). The data indicated that IL-16 enhanced the immunosuppressive effect of IL-10. IL-16-cDNA- and IL-10-cDNA-double-transfected squamous cell carcinoma cell line were used as an in vitro model and they produced more than 20 ng/ml of IL-16 and 100 pg/ml of IL-10 in the supernatant, which significantly inhibited MLR and also the activation of allogeneic lymphocytes, which were stimulated directly by allogeneic double-cDNA-transfectant cells. Thus allogeneic skin graft producing IL-16 and IL-10 might have a local immunosuppressive action that could prolong graft survival. | lld:pubmed |
| pubmed-article:18950955 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18950955 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18950955 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18950955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18950955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18950955 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18950955 | pubmed:month | May | lld:pubmed |
| pubmed-article:18950955 | pubmed:issn | 1879-1409 | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:SatoNoriyukiN | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:SaharaHiroeki... | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:YotsuyanagiTa... | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:CruikshankWil... | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:HiraiItaruI | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:TorigoeToshih... | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:MatsumotoYosh... | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:FujitaTatsuya... | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:EzoeKyoriK | lld:pubmed |
| pubmed-article:18950955 | pubmed:author | pubmed-author:SaitoTamotsuT | lld:pubmed |
| pubmed-article:18950955 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18950955 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:18950955 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18950955 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18950955 | pubmed:pagination | 383-9 | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:meshHeading | pubmed-meshheading:18950955... | lld:pubmed |
| pubmed-article:18950955 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18950955 | pubmed:articleTitle | Immunosuppressive effect on T cell activation by interleukin-16- and interleukin-10-cDNA-double-transfected human squamous cell line. | lld:pubmed |
| pubmed-article:18950955 | pubmed:affiliation | Division of Plastic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan. ymatsu@sapmed.ac.jp | lld:pubmed |
| pubmed-article:18950955 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18950955 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18950955 | lld:pubmed |
