| pubmed-article:18950900 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18950900 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:18950900 | lifeskim:mentions | umls-concept:C0034830 | lld:lifeskim |
| pubmed-article:18950900 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18950900 | lifeskim:mentions | umls-concept:C0597358 | lld:lifeskim |
| pubmed-article:18950900 | lifeskim:mentions | umls-concept:C0205170 | lld:lifeskim |
| pubmed-article:18950900 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18950900 | pubmed:dateCreated | 2010-4-21 | lld:pubmed |
| pubmed-article:18950900 | pubmed:abstractText | Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace eyeblink classical conditioning. Brain tissue from the best and worst young and older learners was analyzed with radioligand binding. Vehicle-treated 4- and 27-month good learners had higher alphabeta heteromeric nAChR binding in hippocampus and temporal-parietal cortex than poor learners, and this result was replicated in both age groups of rabbits treated with galantamine. Results indicate that anatomically more numerous nAChRs or functional activation of a greater number of nAChRs may characterize animals demonstrating optimal learning. During normal aging the expression of high-affinity binding sites declines. Age-related changes in the expression of hippocampal alphabeta heteromeric nAChRs may account for some of the documented age-related impairment in learning. However, individual differences in alphabeta heteromeric nAChRs also exist early in life, as better learning in 4-month rabbits was associated with significantly higher binding. | lld:pubmed |
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| pubmed-article:18950900 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18950900 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18950900 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18950900 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18950900 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18950900 | pubmed:issn | 1558-1497 | lld:pubmed |
| pubmed-article:18950900 | pubmed:author | pubmed-author:LiJian-GuoJG | lld:pubmed |
| pubmed-article:18950900 | pubmed:author | pubmed-author:Liu-ChenLee-Y... | lld:pubmed |
| pubmed-article:18950900 | pubmed:author | pubmed-author:Woodruff-PakD... | lld:pubmed |
| pubmed-article:18950900 | pubmed:author | pubmed-author:LehrMelissa... | lld:pubmed |
| pubmed-article:18950900 | pubmed:copyrightInfo | Copyright 2008 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:18950900 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18950900 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18950900 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18950900 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18950900 | pubmed:pagination | 1032-43 | lld:pubmed |
| pubmed-article:18950900 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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