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pubmed-article:18950269pubmed:abstractTextCerebral vasospasm remains a major complication in patients who have suffered a subarachnoid hemorrhage (SAH). Previous studies have shown that 17beta-estradiol (E2) attenuates experimental SAH-induced cerebral vasospasm. Moreover, E2 has been shown to reduce neuronal apoptosis and secondary injury following cerebral ischemia. Adenosine A1 receptor (AR-A1) expression is increased following ischemia and may represent an endogenous neuroprotective effect. This study was designed to evaluate the efficacy of E2 in preventing cerebral vasospasm and reducing secondary injury, as evidenced by DNA fragmentation and AR-A1 expression, following SAH.lld:pubmed
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pubmed-article:18950269pubmed:articleTitleAttenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage.lld:pubmed
pubmed-article:18950269pubmed:affiliationDepartment of Neurosurgery, Graduate Institute of Medicine, College of Medicine, Taiwan.lld:pubmed
pubmed-article:18950269pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18950269pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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