rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-11-4
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pubmed:abstractText |
Mucin-type O-glycans (O-glycans) are highly expressed in vascular ECs. However, it is not known whether they are important for vascular development. To investigate the roles of EC O-glycans, we generated mice lacking T-synthase, a glycosyltransferase encoded by the gene C1galt1 that is critical for the biosynthesis of core 1-derived O-glycans, in ECs and hematopoietic cells (termed here EHC T-syn(-/-) mice). EHC T-syn(-/-) mice exhibited embryonic and neonatal lethality associated with disorganized and blood-filled lymphatic vessels. Bone marrow transplantation and EC C1galt1 transgene rescue demonstrated that lymphangiogenesis specifically requires EC O-glycans, and intestinal lymphatic microvessels in EHC T-syn(-/-) mice expressed a mosaic of blood and lymphatic EC markers. The level of O-glycoprotein podoplanin was significantly reduced in EHC T-syn(-/-) lymphatics, and podoplanin-deficient mice developed blood-filled lymphatics resembling EHC T-syn(-/-) defects. In addition, postnatal inactivation of C1galt1 caused blood/lymphatic vessel misconnections that were similar to the vascular defects in the EHC T-syn(-/-) mice. One consequence of eliminating T-synthase in ECs and hematopoietic cells was that the EHC T-syn(-/-) pups developed fatty liver disease, because of direct chylomicron deposition via misconnected portal vein and intestinal lymphatic systems. Our studies therefore demonstrate that EC O-glycans control the separation of blood and lymphatic vessels during embryonic and postnatal development, in part by regulating podoplanin expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-10499794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11001067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11064424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11161575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11257140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11377291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11677243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11927535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-11961152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12086857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12205444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12235205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12412020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12464682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12522250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12579039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12654292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12707043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12778167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-12853470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-14745002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-15231832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-15254578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-15385431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-15687262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-15875024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-15994837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16170315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16174766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16212503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16355210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16355211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16355212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16877337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-16950126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17202268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17374637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17495031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17515890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17522591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17556669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-17616532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-18345009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-18519955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-3972906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-7660125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-7774011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-8073287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-8627177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-9096345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18924607-9413399
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:CarmelietPeterP,
pubmed-author:CummingsRichard DRD,
pubmed-author:FuJianxinJ,
pubmed-author:GerhardtHolgerH,
pubmed-author:HermansKarlienK,
pubmed-author:IvanciuLacramioaraL,
pubmed-author:JuTongzhongT,
pubmed-author:LiuXiaoweiX,
pubmed-author:LupuFloreaF,
pubmed-author:McDanielJ MichaelJM,
pubmed-author:McGeeSamuelS,
pubmed-author:NyAnneliiA,
pubmed-author:NyeEmmaE,
pubmed-author:RamirezMaria IMI,
pubmed-author:Silasi-MansatRobertR,
pubmed-author:XiaBaoyunB,
pubmed-author:XiaLijunL
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pubmed:issnType |
Print
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pubmed:volume |
118
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
3725-37
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pubmed:dateRevised |
2011-5-5
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pubmed:meshHeading |
pubmed-meshheading:18924607-Animals,
pubmed-meshheading:18924607-Cells, Cultured,
pubmed-meshheading:18924607-Endothelial Cells,
pubmed-meshheading:18924607-Fatty Liver,
pubmed-meshheading:18924607-Galactosyltransferases,
pubmed-meshheading:18924607-Lymphatic Vessels,
pubmed-meshheading:18924607-Mice,
pubmed-meshheading:18924607-Mice, Transgenic,
pubmed-meshheading:18924607-Microvessels,
pubmed-meshheading:18924607-Transgenes
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pubmed:year |
2008
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pubmed:articleTitle |
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
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pubmed:affiliation |
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|