| pubmed-article:18922470 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18922470 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:18922470 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:18922470 | lifeskim:mentions | umls-concept:C1332722 | lld:lifeskim |
| pubmed-article:18922470 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18922470 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18922470 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18922470 | pubmed:dateCreated | 2008-10-16 | lld:pubmed |
| pubmed-article:18922470 | pubmed:abstractText | Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13, but little is known about the regulation of this essential posttranslational modification. We show that Ser13 of uncomplexed Cdc37 is phosphorylated in vivo, as well as in binary complex with a kinase (C-K), or in ternary complex with Hsp90 and kinase (H-C-K). Whereas pSer13-Cdc37 in the H-C-K complex is resistant to nonspecific phosphatases, it is efficiently dephosphorylated by the chaperone-targeted protein phosphatase 5 (PP5/Ppt1), which does not affect isolated Cdc37. We show that Cdc37 and PP5/Ppt1 associate in Hsp90 complexes in yeast and in human tumor cells, and that PP5/Ppt1 regulates phosphorylation of Ser13-Cdc37 in vivo, directly affecting activation of protein kinase clients by Hsp90-Cdc37. These data reveal a cyclic regulatory mechanism for Cdc37, in which its constitutive phosphorylation is reversed by targeted dephosphorylation in Hsp90 complexes. | lld:pubmed |
| pubmed-article:18922470 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18922470 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18922470 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18922470 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18922470 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:DruMM | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:PearlLaurence... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:PiperPeter... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:WorkmanPaulP | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:VaughanCara... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:PanaretouBarr... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:ProdromouChri... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:NeckersLenL | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:GoodValerie... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:ClarkePaul... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:MollapourMehd... | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:TrumanAndrewA | lld:pubmed |
| pubmed-article:18922470 | pubmed:author | pubmed-author:SmithJennifer... | lld:pubmed |
| pubmed-article:18922470 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18922470 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:18922470 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:18922470 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18922470 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18922470 | pubmed:pagination | 886-95 | lld:pubmed |
| pubmed-article:18922470 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18922470 | pubmed:meshHeading | pubmed-meshheading:18922470... | lld:pubmed |
| pubmed-article:18922470 | pubmed:meshHeading | pubmed-meshheading:18922470... | lld:pubmed |
| pubmed-article:18922470 | pubmed:meshHeading | pubmed-meshheading:18922470... | lld:pubmed |
| pubmed-article:18922470 | pubmed:meshHeading | pubmed-meshheading:18922470... | lld:pubmed |
| pubmed-article:18922470 | pubmed:meshHeading | pubmed-meshheading:18922470... | lld:pubmed |
| pubmed-article:18922470 | pubmed:meshHeading | pubmed-meshheading:18922470... | lld:pubmed |
