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| pubmed-article:1886719 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
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| pubmed-article:1886719 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:1886719 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:1886719 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1886719 | pubmed:dateCreated | 1991-10-4 | lld:pubmed |
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| pubmed-article:1886719 | pubmed:abstractText | Analysis of several cases of t(1:14)(p32;q11) translocation present in 3% of T-cell acute leukemias (T-ALL) has revealed the tal-1 gene. This gene encodes a helix-loop-helix protein. It has been found to be expressed in normal bone marrow and in leukemic T-cell and erythroleukemia cell lines, but not in normal T cells. Recently, a site-specific deletion, tald, renamed tald1 in this paper, has been detected in a high proportion of pediatric T-ALL, which arose by a site-specific DNA recombination between tal-1 and a new locus termed SIL. In this study we searched for structural rearrangements within tal-1 in a panel of 134 non-selected leukemic patients (including 66 with T-ALL). Only 6% of patients with T-ALL harbored the tald1 deletion. A second specific deletion termed tald2 was observed in another 6% of T-ALL patients; it involves another site within tal-1 plus the same site as tald1 in the SIL locus. Similarly to tald1 deletion, tald2 junctions harbor structural characteristics that are reminiscent of aberrant recombinase activity. Moreover, we report a detailed analysis of the tal-1 gene structure. Transcription analysis and in vitro translation data are consistent with the differential expression of several TAL-1 protein species containing the HLH motif but differing in their amino terminus. Taken together, our data indicate that t(1;14) translocations and both tald deletions disrupt the 5' part of the tal-1 gene, placing its entire coding sequences under the control of the regulatory elements of the TCR-delta gene or the SIL gene, both of which are normally expressed in T-cell lineage. | lld:pubmed |
| pubmed-article:1886719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1886719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1886719 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1886719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1886719 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1886719 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:BergerRR | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:LarsenC JCJ | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:MauchaufféMM | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:BernardOO | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:Mathieu-Mahul... | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:SouyriMM | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:JonveauxPP | lld:pubmed |
| pubmed-article:1886719 | pubmed:author | pubmed-author:LecointeNN | lld:pubmed |
| pubmed-article:1886719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1886719 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1886719 | pubmed:geneSymbol | SIL | lld:pubmed |
| pubmed-article:1886719 | pubmed:geneSymbol | tal-1 | lld:pubmed |
| pubmed-article:1886719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1886719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1886719 | pubmed:pagination | 1477-88 | lld:pubmed |
| pubmed-article:1886719 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1886719 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1886719 | pubmed:articleTitle | Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. | lld:pubmed |
| pubmed-article:1886719 | pubmed:affiliation | INSERM U301, Institut de Génétique Moléculaire, Paris, France. | lld:pubmed |
| pubmed-article:1886719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1886719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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