| pubmed-article:18851841 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C0042765 | lld:lifeskim |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18851841 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:18851841 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18851841 | pubmed:dateCreated | 2008-10-14 | lld:pubmed |
| pubmed-article:18851841 | pubmed:abstractText | Cell-density-dependent gene regulation by quorum-sensing systems has a crucial function in bacterial physiology and pathogenesis. We demonstrate here that the Staphylococcus aureus agr quorum-sensing regulon is divided into (1) control of metabolism and PSM cytolysin genes, which occurs independently of the small regulatory RNA RNAIII, and (2) RNAIII-dependent control of additional virulence genes. Remarkably, PSM expression was regulated by direct binding of the AgrA response regulator. Our findings suggest that quorum-sensing regulation of PSMs was established before wide-ranging control of virulence was added to the agr regulon, which likely occurred by development of the RNAIII-encoding region around the gene encoding the PSM delta-toxin. Moreover, the agr regulon in the community-associated methicillin-resistant S. aureus MW2 considerably differed from that previously determined using laboratory strains. By establishing a two-level model of quorum-sensing target gene regulation in S. aureus, our study gives important insight into the evolution of virulence control in this leading human pathogen. | lld:pubmed |
| pubmed-article:18851841 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18851841 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18851841 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18851841 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18851841 | pubmed:issn | 1097-4164 | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:KoçLL | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:SturdevantDan... | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:OttoMichaelM | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:Jameson-LeeMa... | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:VillaruzAmer... | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:BachThanh-Huy... | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:QueckShu YSY | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:KhanBurhan... | lld:pubmed |
| pubmed-article:18851841 | pubmed:author | pubmed-author:RicklefsStace... | lld:pubmed |
| pubmed-article:18851841 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18851841 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18851841 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:18851841 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18851841 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18851841 | pubmed:pagination | 150-8 | lld:pubmed |
| pubmed-article:18851841 | pubmed:dateRevised | 2011-9-28 | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
| pubmed-article:18851841 | pubmed:meshHeading | pubmed-meshheading:18851841... | lld:pubmed |
