pubmed-article:18849890 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C0036341 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C0379900 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C1276996 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:18849890 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:18849890 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:18849890 | pubmed:dateCreated | 2008-12-16 | lld:pubmed |
pubmed-article:18849890 | pubmed:abstractText | The serotonin (5-HT) 1A receptor has been found to be dysregulated in prefrontal cortex and other brain regions in schizophrenia, and 5-HT1A receptor levels in the amygdala have been related to negative schizophrenia symptoms. We have assessed the impact of the functional C-1019G variant of the 5-HT1A receptor on the response to risperidone or haloperidol in a prospective, randomized, double-blind study. Patients were treated for 4 weeks and negative symptoms assessed weekly. The variant influenced the response to risperidone: improvement of negative symptoms by 4.38 points for carriers of the C allele, compared with the GG genotype (1.22 points, P=0.046). In a second independent study of 130 schizophrenia patients treated with atypical antipsychotics, this effect was confirmed (P=0.003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms. | lld:pubmed |
pubmed-article:18849890 | pubmed:language | eng | lld:pubmed |
pubmed-article:18849890 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18849890 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:18849890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18849890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18849890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18849890 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18849890 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18849890 | pubmed:month | Jan | lld:pubmed |
pubmed-article:18849890 | pubmed:issn | 1744-6872 | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:GaebelWolfgan... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:MaierWolfgang... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:RietschelMarc... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:WagnerMichael... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:ZillPeterP | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:RujescuDanD | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:MössnerRainal... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:WölwerWolfgan... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:KühnKai-UweKU | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:QuednowBoris... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:CvetanovskaGa... | lld:pubmed |
pubmed-article:18849890 | pubmed:author | pubmed-author:SchuhmacherAn... | lld:pubmed |
pubmed-article:18849890 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:18849890 | pubmed:volume | 19 | lld:pubmed |
pubmed-article:18849890 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18849890 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18849890 | pubmed:pagination | 91-4 | lld:pubmed |
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pubmed-article:18849890 | pubmed:meshHeading | pubmed-meshheading:18849890... | lld:pubmed |
pubmed-article:18849890 | pubmed:year | 2009 | lld:pubmed |
pubmed-article:18849890 | pubmed:articleTitle | Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia. | lld:pubmed |
pubmed-article:18849890 | pubmed:affiliation | Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. rainald.moessner@ukb.uni-bonn.de | lld:pubmed |
pubmed-article:18849890 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18849890 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
pubmed-article:18849890 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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