| pubmed-article:18849299 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C0007117 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1332817 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18849299 | lifeskim:mentions | umls-concept:C1955901 | lld:lifeskim |
| pubmed-article:18849299 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18849299 | pubmed:dateCreated | 2009-2-5 | lld:pubmed |
| pubmed-article:18849299 | pubmed:abstractText | Stromal cell-derived factor 1alpha (SDF-1alpha) (CXCL12) has been observed to enhance tumor angiogenesis. However, the comprehensive role of SDF-1alpha (CXCL12)-CXCR4 interaction, exerted during angiogenesis, has not been well understood. We have previously demonstrated that human basal cell carcinoma (BCC) tissues and a BCC cell line (BCC-1/KMC) had significant expression of CXCR4, whose level was higher in invasive than in the non-invasive BCC types. Here, we observed that human BCC tissues with high expression levels of CXCR4 had higher vascularity. Further, among the 71 BCCs diagnosed between the years 2004-2005, BCCs with high CXCR4 expression had concomitantly higher microvessel density, as compared with those with low CXCR4 expression (P < 0.001). We found that SDF-1alpha induced angiogenic activity in human BCC cells, both in vitro and in vivo. SDF-1alpha significantly upregulated several angiogenesis-associated genes such as interferon-alpha-inducible protein 27, interleukin (IL)-6, bone morphogenetic protein (BMP)-6, SOCS2 and cyclooxygenase 2 (COX)-2 in human BCC cells. Among them, IL-6 was the earliest and highest upregulated gene whose induction was observed within 6 h of the commencement of SDF-1alpha-CXCR4 interaction. The mechanisms behind the SDF-1alpha-induced time and dose-dependent upregulation of messenger RNA expression and protein secretion of IL-6 were investigated. The transcriptional regulation of IL-6 by SDF-1alpha was mediated by phosphorylation of extracellular signal-related kinase 1/2 and activation of the nuclear factor-kappaB complex. The identification of the angiogenic profiles induced through SDF-1alpha-CXCR4 interactions in human BCC cells may contribute further insights into the mechanisms involved in the angiogenic potential of SDF-1alpha (CXCL12). | lld:pubmed |
| pubmed-article:18849299 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18849299 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18849299 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18849299 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18849299 | pubmed:issn | 1460-2180 | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:KuoMin-LiangM... | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:ChuChia-YuCY | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:JeeShiou-HwaS... | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:TanChing-Ting... | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:ChangCheng-Ch... | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:LinWan-ChiWC | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:ChaShih-TingS... | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:LuPo-HsuanPH | lld:pubmed |
| pubmed-article:18849299 | pubmed:author | pubmed-author:LinBen-RenBR | lld:pubmed |
| pubmed-article:18849299 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18849299 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:18849299 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18849299 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18849299 | pubmed:pagination | 205-13 | lld:pubmed |
| pubmed-article:18849299 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
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| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:meshHeading | pubmed-meshheading:18849299... | lld:pubmed |
| pubmed-article:18849299 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18849299 | pubmed:articleTitle | Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-kappaB/interleukin-6 pathway. | lld:pubmed |
| pubmed-article:18849299 | pubmed:affiliation | Department of Dermatology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. | lld:pubmed |
| pubmed-article:18849299 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18849299 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18849299 | lld:pubmed |
