| pubmed-article:18840307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18840307 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:18840307 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18840307 | lifeskim:mentions | umls-concept:C0751318 | lld:lifeskim |
| pubmed-article:18840307 | lifeskim:mentions | umls-concept:C0683231 | lld:lifeskim |
| pubmed-article:18840307 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:18840307 | lifeskim:mentions | umls-concept:C1521738 | lld:lifeskim |
| pubmed-article:18840307 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18840307 | pubmed:dateCreated | 2008-10-8 | lld:pubmed |
| pubmed-article:18840307 | pubmed:abstractText | Alleles of many genes in the house mouse (Mus musculus domesticus) t complex influence embryonic development, male transmission ratio, male fertility and other traits. Homozygous t lethal alleles cause prenatal lethality, whereas male t semilethal homozygotes and males heterozygous for two complementing t lethal haplotypes are sterile. Without a mechanism maintaining these deleterious genes, t lethals and t semilethals should be eliminated by selection. The mechanism for maintaining them is transmission ratio distortion (TRD), which is said to occur when a t/+ male sires a significantly greater proportion of fetuses carrying his t haplotype (80-100%) than his wild-type chromosome 17. To understand how this selfish DNA functions in trapped populations, the objectives of this study were to examine the structure of t haplotypes in Colorado field populations and to determine transmission ratios in these populations. The data presented here indicate two possible causes for lower than expected transmission ratios in field populations: (1) single-sire fertilization by sperm from mosaic t males may lack all t haplotype genes causing high TRD. (2) t-bearing sperm fertilizing multiple-sire litters are diluted by+sperm from males having the most common genotype (+/+). | lld:pubmed |
| pubmed-article:18840307 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18840307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18840307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18840307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18840307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18840307 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18840307 | pubmed:issn | 1469-5073 | lld:pubmed |
| pubmed-article:18840307 | pubmed:author | pubmed-author:BakerAnn... | lld:pubmed |
| pubmed-article:18840307 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18840307 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:18840307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18840307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18840307 | pubmed:pagination | 331-9 | lld:pubmed |
| pubmed-article:18840307 | pubmed:dateRevised | 2010-12-28 | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:meshHeading | pubmed-meshheading:18840307... | lld:pubmed |
| pubmed-article:18840307 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18840307 | pubmed:articleTitle | Mendelian inheritance of t haplotypes in house mouse ( Mus musculus domesticus) field populations. | lld:pubmed |
| pubmed-article:18840307 | pubmed:affiliation | Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA. mouse@lamar.colostate.edu | lld:pubmed |
| pubmed-article:18840307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18840307 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18840307 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
