| pubmed-article:18838615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18838615 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:18838615 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:18838615 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:18838615 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:18838615 | lifeskim:mentions | umls-concept:C0677626 | lld:lifeskim |
| pubmed-article:18838615 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:18838615 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18838615 | pubmed:dateCreated | 2009-1-16 | lld:pubmed |
| pubmed-article:18838615 | pubmed:abstractText | Hepatitis C virus (HCV) primarily replicates within the liver, leading to hepatitis, fibrosis, and hepatocellular carcinoma. Infection is also associated with B-cell abnormalities, suggesting an association of the virus with B cells. The infectious JFH-1 strain of HCV can bind primary and immortalized B cells but fails to establish productive infection. However, B cell-associated virus readily infects hepatoma cells, showing an enhanced infectivity compared with extracellular virus. B cells express the viral receptors CD81, SR-BI, and the C-type lectins DC-SIGN and L-SIGN. Antibodies specific for SR-BI and DC-SIGN/L-SIGN reduced B-cell transinfection, supporting a role for these molecules in B-cell association with HCV. Stimulation of B cells with CD40 ligand and interleukin-4 promoted their ability to transinfect hepatoma cells. B cell-associated virus is resistant to trypsin proteolysis and HCV-specific neutralizing antibodies, consistent with particle internalization. HCV promoted the adhesion of primary B cells to Huh-7 hepatomas, providing a mechanism for B-cell retention in the infected liver. In summary, B cells may provide a vehicle for HCV to persist and transmit to the liver. | lld:pubmed |
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| pubmed-article:18838615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18838615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18838615 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18838615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18838615 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18838615 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:AdamsDavid... | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:McKeatingJane... | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:GordonJohnJ | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:RickinsonAlan... | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:MutimerDavidD | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:BalfePeterP | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:Shannon-LoweC... | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:StamatakiZani... | lld:pubmed |
| pubmed-article:18838615 | pubmed:author | pubmed-author:ShawJeanJ | lld:pubmed |
| pubmed-article:18838615 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18838615 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18838615 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:18838615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18838615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18838615 | pubmed:pagination | 585-93 | lld:pubmed |
| pubmed-article:18838615 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
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| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
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| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:meshHeading | pubmed-meshheading:18838615... | lld:pubmed |
| pubmed-article:18838615 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18838615 | pubmed:articleTitle | Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells. | lld:pubmed |
| pubmed-article:18838615 | pubmed:affiliation | Hepatitis C Virus Research Group, Division of Immunity and Infection, Institute for Cancer Studies, UK | lld:pubmed |
| pubmed-article:18838615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18838615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18838615 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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