| pubmed-article:18832652 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18832652 | lifeskim:mentions | umls-concept:C0441833 | lld:lifeskim |
| pubmed-article:18832652 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:18832652 | lifeskim:mentions | umls-concept:C0856825 | lld:lifeskim |
| pubmed-article:18832652 | lifeskim:mentions | umls-concept:C1999270 | lld:lifeskim |
| pubmed-article:18832652 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18832652 | pubmed:dateCreated | 2009-1-9 | lld:pubmed |
| pubmed-article:18832652 | pubmed:abstractText | No validated biomarkers exist for acute graft-versus-host disease (GVHD). We screened plasma with antibody microarrays for 120 proteins in a discovery set of 42 patients who underwent transplantation that revealed 8 potential biomarkers for diagnostic of GVHD. We then measured by enzyme-linked immunosorbent assay (ELISA) the levels of these biomarkers in samples from 424 patients who underwent transplantation randomly divided into training (n = 282) and validation (n = 142) sets. Logistic regression analysis of these 8 proteins determined a composite biomarker panel of 4 proteins (interleukin-2-receptor-alpha, tumor-necrosis-factor-receptor-1, interleukin-8, and hepatocyte growth factor) that optimally discriminated patients with and without GVHD. The area under the receiver operating characteristic curve distinguishing these 2 groups in the training set was 0.91 (95% confidence interval, 0.87-0.94) and 0.86 (95% confidence interval, 0.79-0.92) in the validation set. In patients with GVHD, Cox regression analysis revealed that the biomarker panel predicted survival independently of GVHD severity. A panel of 4 biomarkers can confirm the diagnosis of GVHD in patients at onset of clinical symptoms of GVHD and provide prognostic information independent of GVHD severity. | lld:pubmed |
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| pubmed-article:18832652 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18832652 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18832652 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18832652 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18832652 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18832652 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:RoenP BPB | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:HanashSamir... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:KuickRorkR | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:MisekDavid... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:LevineJohn... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:FerraraJames... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:CookeKenneth... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:BraunThomas... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:ClouthierShaw... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:PaczesnySophi... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:ChoiSung WSW | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:WhitfieldJoel... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:JonesDawnD | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:KrijanovskiOl... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:KitkoCarrie... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:BickleyDaniel... | lld:pubmed |
| pubmed-article:18832652 | pubmed:author | pubmed-author:WeyandAngelaA | lld:pubmed |
| pubmed-article:18832652 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18832652 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:18832652 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:18832652 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18832652 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18832652 | pubmed:pagination | 273-8 | lld:pubmed |
| pubmed-article:18832652 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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