| pubmed-article:18827917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18827917 | lifeskim:mentions | umls-concept:C1510802 | lld:lifeskim |
| pubmed-article:18827917 | lifeskim:mentions | umls-concept:C0040808 | lld:lifeskim |
| pubmed-article:18827917 | lifeskim:mentions | umls-concept:C1329978 | lld:lifeskim |
| pubmed-article:18827917 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18827917 | pubmed:dateCreated | 2008-10-1 | lld:pubmed |
| pubmed-article:18827917 | pubmed:abstractText | While clinical trials demonstrate the benefits of blood pressure and cholesterol reduction, medication adherence in clinical practice is problematic. We hypothesized that a single-pill would be superior to a 2-pill regimen for achieving adherence. In this retrospective, cohort study based on pharmacy claims data, patients newly initiated on a calcium channel blocker (CCB) or statin simultaneously or within 30 days, regardless of sequence, were followed (N=4703). Adherence was measured over 6 months as proportion of days covered (PDC). At baseline, mean age was 63.0 years, 51.6% were female, and mean number of other medications was 7.8. Overall, 16.9% of patients were on single-pill amlodipine/atorvastatin, 15.6% amlodipine + atorvastatin, 24.7% amlodipine + other statin, 13.9% other CCB + atorvastatin, 28.9% other CCB + other statin. Percentages of patients achieving adherence (PDC >or= 80%) were: 67.7% amlodipine/atorvastatin; 49.9% amlodipine + atorvastatin; 40.4% amlodipine + other statin; 46.9% other CCB + atorvastatin; 37.4% other CCB +other statin. After adjusting for treatment selection and cohort differences, odds ratios for adherence with amlodipine/atorvastatin were 1.95 (95% confidence interval [CI], 1.80-2.13) vs amlodipine + atorvastatin, 3.10 (95% CI, 2.85-3.38) vs amlodipine + other statin, 2.06 (95% CI, 1.89-2.24) vs other CCB + atorvastatin, 2.85 (95% CI, 2.61-3.10) vs other CCB + other statin (all p<0.0001). Single-pill amlodipine/atorvastatin may provide clinical benefits through improving adherence, offering clinicians a practical solution for cardiovascular risk management. | lld:pubmed |
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| pubmed-article:18827917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18827917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18827917 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18827917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18827917 | pubmed:issn | 1176-6344 | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:FoodyJoAnne... | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:NicholMichael... | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:ThiebaudPatri... | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:PatelBimal... | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:SolomonHenryH | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:TangSimon S... | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:LeslieR... | lld:pubmed |
| pubmed-article:18827917 | pubmed:author | pubmed-author:HondaDennisD | lld:pubmed |
| pubmed-article:18827917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18827917 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:18827917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18827917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18827917 | pubmed:pagination | 673-81 | lld:pubmed |
| pubmed-article:18827917 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18827917 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18827917 | pubmed:articleTitle | Adherence with single-pill amlodipine/atorvastatin vs a two-pill regimen. | lld:pubmed |
| pubmed-article:18827917 | pubmed:affiliation | MedImpact Healthcare Systems, Inc. San Diego, CA, USA. | lld:pubmed |
| pubmed-article:18827917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18827917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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