| pubmed-article:18824612 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18824612 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:18824612 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:18824612 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:18824612 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18824612 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:18824612 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:18824612 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18824612 | pubmed:dateCreated | 2008-11-21 | lld:pubmed |
| pubmed-article:18824612 | pubmed:abstractText | The in vitro and in vivo activities of a killer decapeptide (KP) against influenza A virus is described, and the mechanisms of action are suggested. KP represents the functional internal image of a yeast killer toxin that proved to exert antimicrobial and anti-human immunodeficiency virus type 1 (HIV-1) activities. Treatment with KP demonstrated a significant inhibitory activity on the replication of two strains of influenza A virus in different cell lines, as evaluated by hemagglutination, hemadsorption, and plaque assays. The complete inhibition of virus particle production and a marked reduction of the synthesis of viral proteins (membrane protein and hemagglutinin, in particular) were observed at a KP concentration of 4 microg/ml. Moreover, KP administered intraperitoneally at a dose of 100 microg/mice once a day for 10 days to influenza A/NWS/33 (H1N1) virus-infected mice improved the survival of the animals by 40% and significantly decreased the viral titers in their lungs. Overall, KP appears to be the first anti-idiotypic antibody-derived peptide that displays inhibitory activity and that has a potential therapeutic effect against pathogenic microorganisms, HIV-1, and influenza A virus by different mechanisms of action. | lld:pubmed |
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| pubmed-article:18824612 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18824612 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18824612 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18824612 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18824612 | pubmed:issn | 1098-6596 | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:MaglianiWalte... | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:ContiStefania... | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:PolonelliLuci... | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:ContiGiorgioG | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:NencioniLucia... | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:PalamaraAnna... | lld:pubmed |
| pubmed-article:18824612 | pubmed:author | pubmed-author:SgarbantiRoss... | lld:pubmed |
| pubmed-article:18824612 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18824612 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:18824612 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18824612 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18824612 | pubmed:pagination | 4331-7 | lld:pubmed |
| pubmed-article:18824612 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18824612 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18824612 | pubmed:articleTitle | Therapeutic activity of an anti-idiotypic antibody-derived killer peptide against influenza A virus experimental infection. | lld:pubmed |
| pubmed-article:18824612 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, Microbiology Section, University of Parma, V. le Antonio Gramsci 14, Parma 43100, Italy. | lld:pubmed |
| pubmed-article:18824612 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18824612 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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