| pubmed-article:1881404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0020155 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0008545 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0000970 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0001758 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:1881404 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:1881404 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1881404 | pubmed:dateCreated | 1991-10-3 | lld:pubmed |
| pubmed-article:1881404 | pubmed:abstractText | Paracetamol was given to 10 healthy human volunteers in 3 doses of 1 g each during a period of 8 h. Blood samples for lymphocyte cultures were taken before and 24 h after paracetamol administration. A small but significant increase was found in the frequency of sister-chromatid exchanges (SCE) after intake of paracetamol (0.187 +/- 0.030 per chromosome before and 0.208 +/- 0.024 per chromosome after). After exposure the mean frequency of chromatid breaks per 100 cells was significantly increased (2.16 +/- 1.33 versus 0.33 +/- 0.50 before exposure). Exposure of human lymphocytes in vitro showed that concentrations of paracetamol above 0.1 mM induced inhibition of replicative DNA synthesis. Increased SCE was found in lymphocytes exposed to 1-10 mM paracetamol for 2 h. Furthermore, 0.75-1.5 mM paracetamol exposure for 24 h increased the frequency of chromatid and chromosome breaks in the lymphocytes. The paracetamol-induced SCE and chromosome aberrations may be secondary effects of paracetamol-induced inhibition of DNA synthesis or due to covalent binding of paracetamol metabolite(s) to DNA. | lld:pubmed |
| pubmed-article:1881404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1881404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1881404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1881404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1881404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1881404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1881404 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1881404 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:1881404 | pubmed:author | pubmed-author:BrøggerAA | lld:pubmed |
| pubmed-article:1881404 | pubmed:author | pubmed-author:HongsloJ KJK | lld:pubmed |
| pubmed-article:1881404 | pubmed:author | pubmed-author:HolmeJ AJA | lld:pubmed |
| pubmed-article:1881404 | pubmed:author | pubmed-author:BjørgeCC | lld:pubmed |
| pubmed-article:1881404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1881404 | pubmed:volume | 261 | lld:pubmed |
| pubmed-article:1881404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1881404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1881404 | pubmed:pagination | 1-8 | lld:pubmed |
| pubmed-article:1881404 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:meshHeading | pubmed-meshheading:1881404-... | lld:pubmed |
| pubmed-article:1881404 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1881404 | pubmed:articleTitle | Increased frequency of sister-chromatid exchange and chromatid breaks in lymphocytes after treatment of human volunteers with therapeutic doses of paracetamol. | lld:pubmed |
| pubmed-article:1881404 | pubmed:affiliation | Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway. | lld:pubmed |
| pubmed-article:1881404 | pubmed:publicationType | Journal Article | lld:pubmed |
