| pubmed-article:18811202 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C1567976 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C0449444 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:18811202 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:18811202 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:18811202 | pubmed:dateCreated | 2008-10-10 | lld:pubmed |
| pubmed-article:18811202 | pubmed:abstractText | Directed lithiation of p-tolyl 1-azulenyl sulfone (1) at the 2-position of the azulenyl group was achieved by using lithium 2,2,6,6-tetramethylpiperidide (LTMP). The azulenyllithium thus generated could be efficiently trapped with various electrophiles to form 2-substituted derivatives 2 in moderate to good yields. p-Tolyl 2-trimethylsilyl-1-azulenyl sulfone (2a) was transformed into cyclic sulfone derivative 3a through the directed lithiation in the p-tolyl group and subsequent intramolecular ring closure at the 8-position. 2-(Phenylsulfanyl)-1-azulenyl p-tolyl sulfone (2b) suffered from desulfonylation to form 2-phenylsulfanylazulene (4). The Suzuki coupling reaction of 2-iodo-1-azulenyl p-tolyl sulfone (2d) with arylboronic acids followed by desulfonylation efficiently gave 2-arylazulenes 10. | lld:pubmed |
| pubmed-article:18811202 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18811202 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18811202 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18811202 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18811202 | pubmed:issn | 1520-6904 | lld:pubmed |
| pubmed-article:18811202 | pubmed:author | pubmed-author:MurafujiToshi... | lld:pubmed |
| pubmed-article:18811202 | pubmed:author | pubmed-author:SugiharaYoshi... | lld:pubmed |
| pubmed-article:18811202 | pubmed:author | pubmed-author:KurotobiKeiK | lld:pubmed |
| pubmed-article:18811202 | pubmed:author | pubmed-author:ShibasakiTosh... | lld:pubmed |
| pubmed-article:18811202 | pubmed:author | pubmed-author:OoishiTakeoT | lld:pubmed |
| pubmed-article:18811202 | pubmed:author | pubmed-author:YamanouchiNob... | lld:pubmed |
| pubmed-article:18811202 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18811202 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:18811202 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:18811202 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18811202 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18811202 | pubmed:pagination | 7971-7 | lld:pubmed |
| pubmed-article:18811202 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:meshHeading | pubmed-meshheading:18811202... | lld:pubmed |
| pubmed-article:18811202 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18811202 | pubmed:articleTitle | A new efficient route to 2-substituted azulenes based on sulfonyl group directed lithiation. | lld:pubmed |
| pubmed-article:18811202 | pubmed:affiliation | Graduate School of Medicine, Yamaguchi University, Yamaguchi City 753-8512, Japan. | lld:pubmed |
| pubmed-article:18811202 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18811202 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
