Linked Life Data

18809372

Source:http://linkedlifedata.com/resource/pubmed/id/18809372

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18809372rdf:typepubmed:Citationlld:pubmed
pubmed-article:18809372lifeskim:mentionsumls-concept:C0006837lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0005575lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0023689lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C1527148lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C1510438lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0679622lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C1998793lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0205314lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:18809372lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:18809372pubmed:issue2lld:pubmed
pubmed-article:18809372pubmed:dateCreated2008-10-30lld:pubmed
pubmed-article:18809372pubmed:abstractTextBiotin protein ligase (BPL) is an essential enzyme responsible for the activation of biotin-dependent enzymes through the covalent attachment of biotin. In yeast, disruption of BPL affects important metabolic pathways such as fatty acid biosynthesis and gluconeogenesis. This makes BPL an attractive drug target for new antifungal agents. Here we report the cloning, recombinant expression and purification of BPL from the fungal pathogen Candida albicans. The biotin domains of acetyl CoA carboxylase and pyruvate carboxylase were also cloned and characterised as substrates for BPL. A novel assay was established thereby allowing examination of the enzyme's properties. These findings will facilitate future structural studies as well as screening efforts to identify potential inhibitors.lld:pubmed
pubmed-article:18809372pubmed:languageenglld:pubmed
pubmed-article:18809372pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:citationSubsetIMlld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18809372pubmed:statusMEDLINElld:pubmed
pubmed-article:18809372pubmed:monthNovlld:pubmed
pubmed-article:18809372pubmed:issn1096-0384lld:pubmed
pubmed-article:18809372pubmed:authorpubmed-author:BookerGrant...lld:pubmed
pubmed-article:18809372pubmed:authorpubmed-author:WallaceJohn...lld:pubmed
pubmed-article:18809372pubmed:authorpubmed-author:WilceMatthew...lld:pubmed
pubmed-article:18809372pubmed:authorpubmed-author:BaileyLisa...lld:pubmed
pubmed-article:18809372pubmed:authorpubmed-author:PolyakSteven...lld:pubmed
pubmed-article:18809372pubmed:authorpubmed-author:PendiniNicole...lld:pubmed
pubmed-article:18809372pubmed:issnTypeElectroniclld:pubmed
pubmed-article:18809372pubmed:day15lld:pubmed
pubmed-article:18809372pubmed:volume479lld:pubmed
pubmed-article:18809372pubmed:ownerNLMlld:pubmed
pubmed-article:18809372pubmed:authorsCompleteYlld:pubmed
pubmed-article:18809372pubmed:pagination163-9lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:meshHeadingpubmed-meshheading:18809372...lld:pubmed
pubmed-article:18809372pubmed:year2008lld:pubmed
pubmed-article:18809372pubmed:articleTitleBiotin protein ligase from Candida albicans: expression, purification and development of a novel assay.lld:pubmed
pubmed-article:18809372pubmed:affiliationSchool of Molecular and Biomedical Science, University of Adelaide, Molecular Lifesciences Building, North Tce, Adelaide, SA 5005, Australia.lld:pubmed
pubmed-article:18809372pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18809372pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18809372lld:pubmed