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pubmed-article:18809348pubmed:abstractTextWe previously reported that activated neutrophils are critically involved in the development of stress-induced gastric mucosal injury in mice. Caspase activation plays an important role in the pathogenesis of tissue injury by activating neutrophils through an increase in the expression of endothelial monocyte-activating polypeptide-II (EMAP-II), a chemoattractant for neutrophils. Since insulin-like growth factor-I (IGF-I) inhibits caspase activation, it is possible that IGF-I reduces gastric mucosal injury by inhibiting neutrophil activation. In the present study, we examined this possibility in mice subjected to water-immersion restraint stress (WIR).lld:pubmed
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pubmed-article:18809348pubmed:articleTitleInsulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice.lld:pubmed
pubmed-article:18809348pubmed:affiliationDepartment of Anesthesiology and Medical Crisis Management, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.lld:pubmed
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