| pubmed-article:18802953 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C0034011 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C1418596 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C1708248 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C0018067 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C0015895 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:18802953 | lifeskim:mentions | umls-concept:C1524057 | lld:lifeskim |
| pubmed-article:18802953 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18802953 | pubmed:dateCreated | 2008-10-23 | lld:pubmed |
| pubmed-article:18802953 | pubmed:abstractText | This report introduces a gonadotrope-specific cre transgenic mouse capable of ablating floxed genes in mature pituitary gonadotropes. Initial analysis of this transgenic line, Tg(Lhb-cre)1Sac, reveals that expression is limited to the pituitary cells that produce luteinizing hormone beta, beginning appropriately at e17.5. Cre activity is detectable by a reporter gene in nearly every LHbeta-producing cell, but the remaining hormone-producing cell types and other organs exhibit little to no activity. We used the Tg(Lhb-cre)1Sac strain to assess the role Pitx2 in gonadotrope function. The gonadotrope-specific Pitx2 knockout mice exhibit normal expression of LHbeta, sexual maturation, and fertility, suggesting that Pitx2 is not required for gonadotrope maintenance or for regulated production of gonadotropins. | lld:pubmed |
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| pubmed-article:18802953 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18802953 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18802953 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18802953 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18802953 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18802953 | pubmed:issn | 1526-968X | lld:pubmed |
| pubmed-article:18802953 | pubmed:author | pubmed-author:CamperSally... | lld:pubmed |
| pubmed-article:18802953 | pubmed:author | pubmed-author:PotokMary... | lld:pubmed |
| pubmed-article:18802953 | pubmed:author | pubmed-author:CharlesMichae... | lld:pubmed |
| pubmed-article:18802953 | pubmed:author | pubmed-author:MortensenAman... | lld:pubmed |
| pubmed-article:18802953 | pubmed:copyrightInfo | Copyright 2008 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:18802953 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18802953 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:18802953 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18802953 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18802953 | pubmed:pagination | 507-14 | lld:pubmed |
| pubmed-article:18802953 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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| pubmed-article:18802953 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18802953 | pubmed:articleTitle | Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility. | lld:pubmed |
| pubmed-article:18802953 | pubmed:affiliation | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618, USA. | lld:pubmed |
| pubmed-article:18802953 | pubmed:publicationType | Journal Article | lld:pubmed |
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