| pubmed-article:18784291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C0626201 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C0051334 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:18784291 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:18784291 | pubmed:issue | 37 | lld:pubmed |
| pubmed-article:18784291 | pubmed:dateCreated | 2008-9-11 | lld:pubmed |
| pubmed-article:18784291 | pubmed:abstractText | Both the neuregulin 1 (Nrg1) and alpha7 nicotinic acetylcholine receptor (alpha7*nAChRs) genes have been linked to schizophrenia and associated sensory-motor gating deficits. The prominence of nicotine addiction in schizophrenic patients is reflected in the normalization of gating deficits by nicotine self-administration. To assess the role of presynaptic type III Nrg1 at hippocampal-accumbens synapses, an important relay in sensory-motor gating, we developed a specialized preparation of chimeric circuits in vitro. Synaptic relays from Nrg1(tm1Lwr) heterozygote ventral hippocampal slices to wild-type (WT) nucleus accumbens neurons (1) lack a sustained, alpha7*nAChRs-mediated phase of synaptic potentiation seen in comparable WT/WT circuits and (2) are deficient in targeting alpha7*nAChRs to presynaptic sites. Thus, selective alteration of the level of presynaptic type III Nrg1 dramatically affects the modulation of glutamatergic transmission at ventral hippocampal to nucleus accumbens synapses. | lld:pubmed |
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| pubmed-article:18784291 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18784291 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18784291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18784291 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18784291 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:18784291 | pubmed:author | pubmed-author:RoleLorna WLW | lld:pubmed |
| pubmed-article:18784291 | pubmed:author | pubmed-author:TalmageDavid... | lld:pubmed |
| pubmed-article:18784291 | pubmed:author | pubmed-author:DuChuangC | lld:pubmed |
| pubmed-article:18784291 | pubmed:author | pubmed-author:ZhongChongboC | lld:pubmed |
| pubmed-article:18784291 | pubmed:author | pubmed-author:HancockMeliss... | lld:pubmed |
| pubmed-article:18784291 | pubmed:author | pubmed-author:MertzMarjolij... | lld:pubmed |
| pubmed-article:18784291 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18784291 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18784291 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:18784291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18784291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18784291 | pubmed:pagination | 9111-6 | lld:pubmed |
| pubmed-article:18784291 | pubmed:dateRevised | 2010-6-4 | lld:pubmed |
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