| pubmed-article:18784250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18784250 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18784250 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18784250 | lifeskim:mentions | umls-concept:C1426757 | lld:lifeskim |
| pubmed-article:18784250 | lifeskim:mentions | umls-concept:C1157980 | lld:lifeskim |
| pubmed-article:18784250 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:18784250 | pubmed:dateCreated | 2008-10-29 | lld:pubmed |
| pubmed-article:18784250 | pubmed:abstractText | Clearance of misfolded proteins from the ER is central for maintenance of cellular homeostasis. This process requires coordinated recognition, ER-cytosol translocation, and finally ubiquitination-dependent proteasomal degradation. Here, we identify an ER resident seven-transmembrane protein (JAMP) that links ER chaperones, channel proteins, ubiquitin ligases, and 26S proteasome subunits, thereby optimizing degradation of misfolded proteins. Elevated JAMP expression promotes localization of proteasomes at the ER, with a concomitant effect on degradation of specific ER-resident misfolded proteins, whereas inhibiting JAMP promotes the opposite response. Correspondingly, a jamp-1 deleted Caenorhabditis elegans strain exhibits hypersensitivity to ER stress and increased UPR. Using biochemical and genetic approaches, we identify JAMP as important component for coordinated clearance of misfolded proteins from the ER. | lld:pubmed |
| pubmed-article:18784250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18784250 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18784250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18784250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18784250 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18784250 | pubmed:issn | 1939-4586 | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:Erdjument-Bro... | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:TempstPaulP | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:RonaiZe'evZ | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:DeMartinoGeor... | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:TcherpakovMar... | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:KadoyaTakayuk... | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:BrodayLimorL | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:KhuranaAshwan... | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:QiuXiao-BoXB | lld:pubmed |
| pubmed-article:18784250 | pubmed:author | pubmed-author:DelaunayAgnes... | lld:pubmed |
| pubmed-article:18784250 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18784250 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18784250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18784250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18784250 | pubmed:pagination | 5019-28 | lld:pubmed |
| pubmed-article:18784250 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:meshHeading | pubmed-meshheading:18784250... | lld:pubmed |
| pubmed-article:18784250 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18784250 | pubmed:articleTitle | JAMP optimizes ERAD to protect cells from unfolded proteins. | lld:pubmed |
| pubmed-article:18784250 | pubmed:affiliation | Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:18784250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18784250 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18784250 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:178993 | entrezgene:pubmed | pubmed-article:18784250 | lld:entrezgene |
| entrez-gene:51528 | entrezgene:pubmed | pubmed-article:18784250 | lld:entrezgene |
| entrez-gene:104771 | entrezgene:pubmed | pubmed-article:18784250 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18784250 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18784250 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18784250 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18784250 | lld:pubmed |
