| pubmed-article:18781290 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18781290 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:18781290 | lifeskim:mentions | umls-concept:C0439660 | lld:lifeskim |
| pubmed-article:18781290 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:18781290 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:18781290 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:18781290 | lifeskim:mentions | umls-concept:C2931784 | lld:lifeskim |
| pubmed-article:18781290 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18781290 | pubmed:dateCreated | 2009-2-12 | lld:pubmed |
| pubmed-article:18781290 | pubmed:abstractText | We report a patient with early-onset autosomal dominant dementia. The CSF showed increased levels of tau protein and decreased amyloid beta (ratio 42:40) typical for Alzheimer's disease. Cerebral MRI revealed vascular lesions and white-matter changes around the posterior horns of the ventricles with only moderate atrophy of the brain. Susceptibility-weighted imaging detected multiple small hemorrhagic changes. Gene analysis revealed amyloid precursor protein (APP) locus duplication as the cause of hereditary Alzheimer's dementia. The co-occurrence of CSF changes typical for Alzheimer's disease and MRI findings of cerebral amyloid angiopathy is remarkable, as it is also described for APP locus duplication. In conjunction with a family history suggestive of hereditary dementia, such a constellation should lead to enhanced gene analysis. | lld:pubmed |
| pubmed-article:18781290 | pubmed:language | ger | lld:pubmed |
| pubmed-article:18781290 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18781290 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18781290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18781290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18781290 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18781290 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18781290 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18781290 | pubmed:issn | 1433-0407 | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:SauerHH | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:WilhelmCC | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:KunzeAA | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:ZhaY RYR | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:AxerHH | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:ReichenbachJ... | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:KohlhaseJJ | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:FreesmeyerMM | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:AxerMM | lld:pubmed |
| pubmed-article:18781290 | pubmed:author | pubmed-author:MageSS | lld:pubmed |
| pubmed-article:18781290 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18781290 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:18781290 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18781290 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18781290 | pubmed:pagination | 62-3, 65-7 | lld:pubmed |
| pubmed-article:18781290 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:meshHeading | pubmed-meshheading:18781290... | lld:pubmed |
| pubmed-article:18781290 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18781290 | pubmed:articleTitle | [Hereditary Alzheimer's disease with amyloid angiopathy caused by amyloid precursor protein locus]. | lld:pubmed |
| pubmed-article:18781290 | pubmed:affiliation | Klinik für Psychiatrie und Psychotherapie, Friedrich-Schiller-Universität, Jena, Deutschland. Hubertus.Axer@med.uni-jena.de | lld:pubmed |
| pubmed-article:18781290 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18781290 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:18781290 | pubmed:publicationType | Case Reports | lld:pubmed |
