Linked Life Data

18779325

Source:http://linkedlifedata.com/resource/pubmed/id/18779325

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18779325rdf:typepubmed:Citationlld:pubmed
pubmed-article:18779325lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0018787lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0031686lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0221099lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0596019lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C1420091lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C1420195lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C1832073lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C1621574lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0596235lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0597484lld:lifeskim
pubmed-article:18779325lifeskim:mentionsumls-concept:C0598850lld:lifeskim
pubmed-article:18779325pubmed:issue46lld:pubmed
pubmed-article:18779325pubmed:dateCreated2008-11-10lld:pubmed
pubmed-article:18779325pubmed:abstractTextTo analyze the cardiac functions of AE3, we disrupted its gene (Slc4a3) in mice. Cl(-)/HCO3(-) exchange coupled with Na+-dependent acid extrusion can mediate pH-neutral Na+ uptake, potentially affecting Ca2+ handling via effects on Na+/Ca2+ exchange. AE3 null mice appeared normal, however, and AE3 ablation had no effect on ischemia-reperfusion injury in isolated hearts or cardiac performance in vivo. The NKCC1 Na+-K+-2Cl(-) cotransporter also mediates Na+ uptake, and loss of NKCC1 alone does not impair contractility. To further stress the AE3-deficient myocardium, we combined the AE3 and NKCC1 knock-outs. Double knock-outs had impaired contraction and relaxation both in vivo and in isolated ventricular myocytes. Ca2+ transients revealed an apparent increase in Ca2+ clearance in double null cells. This was unlikely to result from increased Ca2+ sequestration, since the ratio of phosphorylated phospholamban to total phospholamban was sharply reduced in all three mutant hearts. Instead, Na+/Ca2+ exchanger activity was found to be enhanced in double null cells. Systolic Ca2+ was unaltered, however, suggesting more direct effects on the contractile apparatus of double null myocytes. Expression of the catalytic subunit of protein phosphatase 1 was increased in all mutant hearts. There was also a dramatic reversal, between single null and double null hearts, in the carboxymethylation and localization to the myofibrillar fraction, of the catalytic subunit of protein phosphatase 2A, which corresponded to the loss of normal contractility in double null hearts. These data show that AE3 and NKCC1 affect Ca2+ handling, PLN regulation, and expression and localization of major cardiac phosphatases and that their combined loss impairs cardiac function.lld:pubmed
pubmed-article:18779325pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:languageenglld:pubmed
pubmed-article:18779325pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:citationSubsetIMlld:pubmed
pubmed-article:18779325pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18779325pubmed:statusMEDLINElld:pubmed
pubmed-article:18779325pubmed:monthNovlld:pubmed
pubmed-article:18779325pubmed:issn0021-9258lld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:MillerMarian...lld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:ShullGary EGElld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:AshrafMuhamma...lld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:NiemanMichell...lld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:DoetschmanTho...lld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:LorenzJohn...lld:pubmed
pubmed-article:18779325pubmed:authorpubmed-author:BodiIlonaIlld:pubmed
More...