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pubmed-article:18772215pubmed:abstractTextNeurotoxicity of intrathecal (IT) chemotherapy has been variously attributed to the preservatives, volume, osmolality, and pH of the preparations. There has been little evaluation of how different drug concentrations or diluents can affect the osmolality and pH of the final solution. We conducted a three-part study: survey of cancer centers regarding the drug concentrations and diluent used in preparing IT chemotherapy; review of the literature on common practice of preparing IT chemotherapy; evaluation of the pH and osmolality of commonly used chemotherapy preparations for IT.lld:pubmed
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pubmed-article:18772215pubmed:articleTitleEvaluation of osmolality and pH of various concentrations of methotrexate, cytarabine, and thiotepa prepared in normal saline, sterile water for injection, and lactated Ringer's solution for intrathecal administration.lld:pubmed
pubmed-article:18772215pubmed:affiliationProvincial Systemic Therapy Program, BC Cancer Agency, Vancouver, BC, Canada. mdelemos@bccancer.bc.calld:pubmed
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